Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2.
Animals
Anti-Bacterial Agents
/ pharmacology
Cattle
Clioquinol
/ analogs & derivatives
Female
Ionophores
/ pharmacology
Mastitis, Bovine
/ microbiology
Oxidative Stress
/ drug effects
Reactive Oxygen Species
/ metabolism
Streptococcus
/ drug effects
Superoxide Dismutase
/ antagonists & inhibitors
Zinc
/ metabolism
PBT2
antimicrobial resistance
ionophore
manganese
metal ion homeostasis
oxidative stress
zinc
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
18 03 2020
18 03 2020
Historique:
entrez:
20
3
2020
pubmed:
20
3
2020
medline:
17
3
2021
Statut:
epublish
Résumé
Globally, more antimicrobials are used in food-producing animals than in humans, and the extensive use of medically important human antimicrobials poses a significant public health threat in the face of rising antimicrobial resistance (AMR). The development of novel ionophores, a class of antimicrobials used exclusively in animals, holds promise as a strategy to replace or reduce essential human antimicrobials in veterinary practice. PBT2 is a zinc ionophore with recently demonstrated antibacterial activity against several Gram-positive pathogens, although the underlying mechanism of action is unknown. Here, we investigated the bactericidal mechanism of PBT2 in the bovine mastitis-causing pathogen,
Identifiants
pubmed: 32188750
pii: 5/2/e00157-20
doi: 10.1128/mSphere.00157-20
pmc: PMC7082140
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Ionophores
0
PBT2 compound
0
Reactive Oxygen Species
0
Clioquinol
7BHQ856EJ5
Superoxide Dismutase
EC 1.15.1.1
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Harbison-Price et al.
Références
Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S407-11
pubmed: 6356275
Nat Rev Microbiol. 2012 Jul 16;10(8):525-37
pubmed: 22796883
Metallomics. 2011 Jan;3(1):38-41
pubmed: 21275153
J Bacteriol. 1981 Jun;146(3):928-36
pubmed: 6263860
Infect Immun. 2003 Sep;71(9):4842-9
pubmed: 12933824
Curr Opin Chem Biol. 2010 Apr;14(2):218-24
pubmed: 20015678
Nat Rev Microbiol. 2017 Jun;15(6):338-350
pubmed: 28344348
J Biol Chem. 2015 Jul 31;290(31):18954-61
pubmed: 26055706
Curr Microbiol. 2016 Apr;72(4):377-82
pubmed: 26687332
Appl Environ Microbiol. 2003 Oct;69(10):5739-45
pubmed: 14532020
PLoS Pathog. 2011 Nov;7(11):e1002357
pubmed: 22072971
Genome Announc. 2018 Mar 1;6(9):
pubmed: 29496837
Pharmacol Rev. 1998 Sep;50(3):335-56
pubmed: 9755286
FEMS Microbiol Rev. 2003 Apr;27(1):65-74
pubmed: 12697342
Lancet Neurol. 2008 Sep;7(9):779-86
pubmed: 18672400
mBio. 2018 Dec 11;9(6):
pubmed: 30538186
Alzheimers Dement (N Y). 2017 Nov 09;3(4):622-635
pubmed: 29201996
Rev Sci Tech. 2012 Apr;31(1):145-88
pubmed: 22849274
Lancet Neurol. 2015 Jan;14(1):39-47
pubmed: 25467848
J Antimicrob Chemother. 2003 Jul;52(1):1
pubmed: 12805255
PLoS Genet. 2016 Dec 9;12(12):e1006515
pubmed: 27935957
J Biol Chem. 2011 May 20;286(20):17831-40
pubmed: 21454507
Lancet. 2005 Feb 12-18;365(9459):579-87
pubmed: 15708101
Proc Natl Acad Sci U S A. 1990 Jan;87(1):389-93
pubmed: 2296594
J Infect Dis. 2014 May 15;209(10):1500-8
pubmed: 24449444
J Bacteriol. 2002 Jun;184(11):2931-9
pubmed: 12003933
Infect Immun. 2013 Feb;81(2):421-9
pubmed: 23184523
Ir Vet J. 2009 Apr 01;62 Suppl 4:S40-44
pubmed: 22081939
Int J Antimicrob Agents. 2015 Nov;46(5):582-5
pubmed: 26421981
J Neurochem. 2011 Oct;119(1):220-30
pubmed: 21797865
Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7326-7331
pubmed: 29941569
mBio. 2018 May 29;9(3):
pubmed: 29844113
Transbound Emerg Dis. 2018 May;65 Suppl 1:166-185
pubmed: 29083115
J Biol Chem. 2014 Oct 10;289(41):28095-103
pubmed: 25160626
Neuron. 2008 Jul 10;59(1):43-55
pubmed: 18614028
PLoS One. 2014 Feb 18;9(2):e89427
pubmed: 24558498
Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5402-7
pubmed: 21402925
Pathog Glob Health. 2015 Jun;109(4):184-92
pubmed: 26184804
J Med Microbiol. 2017 Dec;66(12):1744-1751
pubmed: 29134935
BMC Genomics. 2015 Oct 19;16:821
pubmed: 26482235
Arch Biochem Biophys. 1982 Apr 1;214(2):452-63
pubmed: 6284026
Adv Microb Physiol. 2009;55:1-79, 317
pubmed: 19573695
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
J Microbiol Methods. 2001 Mar 1;44(2):121-9
pubmed: 11165341
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5649-54
pubmed: 25792457
Vet J. 2002 Sep;164(2):116-28
pubmed: 12359466
Mol Microbiol. 2002 Jun;44(5):1269-86
pubmed: 12028379
Mol Microbiol. 2012 Dec;86(5):1144-55
pubmed: 23057863
Microbiology. 2001 Apr;147(Pt 4):1017-1024
pubmed: 11283297
Mol Microbiol. 2005 Oct;58(2):533-51
pubmed: 16194238
Infect Immun. 2003 May;71(5):2656-64
pubmed: 12704140
Nat Rev Microbiol. 2013 Jul;11(7):443-54
pubmed: 23712352
J Biol Chem. 2012 Apr 20;287(17):13541-8
pubmed: 22247543
Am J Med. 1987 Apr 27;82(4A):12-20
pubmed: 3034057
Metallomics. 2017 Dec 1;9(12):1693-1702
pubmed: 29043347
Biochem J. 2019 Feb 14;476(3):595-611
pubmed: 30670571
Infect Immun. 2018 May 22;86(6):
pubmed: 29581188