Metabolic control analysis of hepatic glycogen synthesis in vivo.
Animals
Diet, High-Fat
/ adverse effects
Disease Models, Animal
Fatty Liver
/ etiology
Gene Knockdown Techniques
Glucokinase
/ genetics
Glucose
/ administration & dosage
Glucose-6-Phosphate
/ analysis
Humans
Hyperglycemia
/ etiology
Hyperinsulinism
/ etiology
Insulin
/ metabolism
Insulin Resistance
Liver
/ metabolism
Liver Glycogen
/ biosynthesis
Male
Metabolomics
Phosphorylation
Rats
glucokinase
hepatic glycogen synthesis
hepatic insulin resistance
in vivo
metabolic control analysis
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
07 04 2020
07 04 2020
Historique:
pubmed:
20
3
2020
medline:
21
7
2020
entrez:
20
3
2020
Statut:
ppublish
Résumé
Multiple insulin-regulated enzymes participate in hepatic glycogen synthesis, and the rate-controlling step responsible for insulin stimulation of glycogen synthesis is unknown. We demonstrate that glucokinase (GCK)-mediated glucose phosphorylation is the rate-controlling step in insulin-stimulated hepatic glycogen synthesis in vivo, by use of the somatostatin pancreatic clamp technique using [
Identifiants
pubmed: 32188779
pii: 1921694117
doi: 10.1073/pnas.1921694117
pmc: PMC7149488
doi:
Substances chimiques
Insulin
0
Liver Glycogen
0
Glucose-6-Phosphate
56-73-5
Glucokinase
EC 2.7.1.2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8166-8176Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114793
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116774
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK108283
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119968
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK045735
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034989
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113984
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA021984
Pays : United States
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: A.V. serves on an advisory board for vTv Therapeutics.
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