Burden of Adults Hospitalized With Group B Streptococcal Infection.
Group B Streptococcus (GBS)
adults
epidemiology
incidence
noninvasive
risk factor
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
13 10 2021
13 10 2021
Historique:
received:
05
12
2019
accepted:
17
03
2020
pubmed:
20
3
2020
medline:
25
2
2022
entrez:
20
3
2020
Statut:
ppublish
Résumé
The burden of noninvasive group B Streptococcus (GBS) infections in adults is unknown. We determined population-based rates of hospitalization where invasive or noninvasive GBS infections were identified among US adults in a defined catchment area. We identified adults with clinical and laboratory-confirmed evidence of GBS infection from January 2014 through December 2016 from 6 hospitals in Louisville, Kentucky. Invasive disease was defined as GBS isolated from a normally sterile site. Among 1076 adults with GBS infection, the median age was 52 years, 51% were male, and 89% had ≥1 chronic medical condition. The most prevalent infection sites were skin and soft tissue (39%), urinary tract (23%), bone and joint (16%), and bloodstream (11%). Forty percent of infections were polymicrobial. The annual incidence of GBS-associated hospitalization was 73 per 100 000 adults and 68 and 100 per 100 000 for patients aged 18-64 and ≥ 65 years, respectively. For every invasive GBS infection, 3.7 noninvasive infections occurred. Our population-based study outlines the full burden of GBS-associated hospitalization in adults and found incidence rates comparable to those of pneumococcal disease, where vaccines are recommended. Noninvasive disease was 3-4 times more common than invasive disease, suggesting that the GBS burden among adults is considerably greater than previously recognized.
Sections du résumé
BACKGROUND
The burden of noninvasive group B Streptococcus (GBS) infections in adults is unknown. We determined population-based rates of hospitalization where invasive or noninvasive GBS infections were identified among US adults in a defined catchment area.
METHODS
We identified adults with clinical and laboratory-confirmed evidence of GBS infection from January 2014 through December 2016 from 6 hospitals in Louisville, Kentucky. Invasive disease was defined as GBS isolated from a normally sterile site.
RESULTS
Among 1076 adults with GBS infection, the median age was 52 years, 51% were male, and 89% had ≥1 chronic medical condition. The most prevalent infection sites were skin and soft tissue (39%), urinary tract (23%), bone and joint (16%), and bloodstream (11%). Forty percent of infections were polymicrobial. The annual incidence of GBS-associated hospitalization was 73 per 100 000 adults and 68 and 100 per 100 000 for patients aged 18-64 and ≥ 65 years, respectively. For every invasive GBS infection, 3.7 noninvasive infections occurred.
CONCLUSIONS
Our population-based study outlines the full burden of GBS-associated hospitalization in adults and found incidence rates comparable to those of pneumococcal disease, where vaccines are recommended. Noninvasive disease was 3-4 times more common than invasive disease, suggesting that the GBS burden among adults is considerably greater than previously recognized.
Identifiants
pubmed: 32188975
pii: 5809927
doi: 10.1093/infdis/jiaa110
pmc: PMC8561246
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1170-1178Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.
Références
Expert Rev Anti Infect Ther. 2019 Jan;17(1):17-25
pubmed: 30518267
Open Forum Infect Dis. 2018 Jun 08;5(6):ofy030
pubmed: 29977953
N Engl J Med. 1993 Jun 24;328(25):1807-11
pubmed: 8502269
Curr Opin Infect Dis. 2018 Apr;31(2):104-112
pubmed: 29337704
Int J Infect Dis. 2019 Jun;83:116-129
pubmed: 31028879
Clin Infect Dis. 2017 Nov 13;65(11):1806-1812
pubmed: 29020164
JAMA Intern Med. 2019 Apr 1;179(4):479-488
pubmed: 30776079
Clin Infect Dis. 2001 Aug 15;33(4):556-61
pubmed: 11462195
JAMA. 1991 Aug 28;266(8):1112-4
pubmed: 1865545
J Pediatr. 1973 Dec;83(6):919-25
pubmed: 4585831
Epidemiol Infect. 2015 Nov;143(15):3343-50
pubmed: 26418351
MMWR Recomm Rep. 2010 Nov 19;59(RR-10):1-36
pubmed: 21088663
J Infect Dis. 2019 Jun 5;220(1):105-115
pubmed: 30778554
N Engl J Med. 2015 Feb 26;372(9):835-45
pubmed: 25714161
MMWR Recomm Rep. 2002 Aug 16;51(RR-11):1-22
pubmed: 12211284
Infection. 2008 Mar;36(2):100-11
pubmed: 18193384
J Med Microbiol. 1998 Jul;47(7):649-52
pubmed: 9839570
MMWR Morb Mortal Wkly Rep. 2014 Sep 19;63(37):822-5
pubmed: 25233284
Clin Infect Dis. 2013 Sep;57(5):682-8
pubmed: 23845950
Clin Infect Dis. 2009 Jul 1;49(1):85-92
pubmed: 19480572