Frequency of thyroid nodules and thyroid cancer in thyroidectomized patients with Graves' disease.
Graves’ disease
thyroid cancer
thyroid nodule
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
10
2018
accepted:
30
11
2018
entrez:
20
3
2020
pubmed:
11
1
2019
medline:
11
1
2019
Statut:
epublish
Résumé
Incidental thyroid cancers are frequently detected in patients operated on for Graves' disease (GD). There are no clear data about the incidence and risk factors of incidental thyroid cancer in operated GD patients. The aim of this study is to evaluate the risk of thyroid carcinoma in surgically treated GD patients. The data of 121 GD patients who underwent total thyroidectomy in a single center between 2005 and 2015 were retrospectively evaluated. The diagnosis of thyroid cancer was based on pathological examination. Thyroid cancer was demonstrated in postoperative pathology specimens of 34 patients who were surgically treated for GD (28.1%). Preoperative thyroid ultrasonography (USG) revealed a nodular goiter in 62 (51.2%) patients. Nodules were not detected in the other 59 (48.8%) patients with GD. The frequency of thyroid cancer was significantly higher in patients with nodules (38% vs. 16%; The incidence of thyroid cancer was higher in patients who underwent surgery for GD. In addition to a careful physical examination in the follow-up of the patients with GD, ultrasonographic evaluation should be performed. Surgical treatment should not be delayed in patients with GD when indicated.
Identifiants
pubmed: 32190140
doi: 10.5114/aoms.2018.81136
pii: 34613
pmc: PMC7069426
doi:
Types de publication
Journal Article
Langues
eng
Pagination
302-307Informations de copyright
Copyright: © 2019 Termedia & Banach.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Int J Surg. 2016 Mar;27:118-25
pubmed: 26626367
Eur J Endocrinol. 2007 Sep;157(3):325-9
pubmed: 17766715
Arch Med Sci. 2017 Oct;13(6):1416-1426
pubmed: 29181073
Am J Surg. 2006 Mar;191(3):400-5
pubmed: 16490555
Ann Surg Oncol. 2004 Apr;11(4):407-12
pubmed: 15070601
Am J Otolaryngol. 2014 Nov-Dec;35(6):784-90
pubmed: 25128909
J Clin Endocrinol Metab. 2013 Mar;98(3):1014-21
pubmed: 23348395
JAMA. 2015 Dec 15;314(23):2544-54
pubmed: 26670972
J Laryngol Otol. 2008 Mar;122(3):291-5
pubmed: 17697433
J Clin Endocrinol Metab. 1998 Aug;83(8):2805-9
pubmed: 9709951
Horm Res. 2003;60(2):79-83
pubmed: 12876418
Eur J Intern Med. 2003 Aug;14(5):321-325
pubmed: 13678758
Am J Surg. 2008 Mar;195(3):292-7; discussion 297
pubmed: 18206132
J Endocrinol Invest. 1988 Feb;11(2):107-12
pubmed: 3361079
World J Surg. 1990 May-Jun;14(3):437-40; discussion 440-1
pubmed: 2368449
Thyroid. 2017 Jun;27(6):825-831
pubmed: 28457178
J Clin Endocrinol Metab. 1990 Apr;70(4):830-5
pubmed: 2180978
ANZ J Surg. 2014 Apr;84(4):231-4
pubmed: 22985335
World J Surg. 2014 Jan;38(1):80-7
pubmed: 24166025
Clin Endocrinol (Oxf). 2001 Dec;55(6):711-8
pubmed: 11895209
Arq Bras Endocrinol Metabol. 2014 Dec;58(9):933-8
pubmed: 25627049
N Engl J Med. 1988 Mar 24;318(12):753-9
pubmed: 3347223
Thyroid. 2014 Feb;24(2):347-54
pubmed: 23786233
J Clin Endocrinol Metab. 1992 Sep;75(3):886-9
pubmed: 1517381
Ann Intern Med. 1968 Sep;69(3):537-40
pubmed: 5673172
Endocr Pathol. 2015 Mar;26(1):48-53
pubmed: 25332114