The role of myelin damage in Alzheimer's disease pathology.
Alzheimer’s disease
myelin impairment
oligodendroglia
white matter damage
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
01
2018
accepted:
30
04
2018
entrez:
20
3
2020
pubmed:
28
8
2018
medline:
28
8
2018
Statut:
epublish
Résumé
Although Alois Alzheimer described myelin disruption in Alzheimer's disease (AD) as early as in 1911, his observation has escaped the attention of researchers since that time. Alzheimer's disease has been mainly considered as a grey matter disorder; nevertheless, recent evidence suggests that myelin impairment may play an important role in AD pathology. Classical neuropathological changes in AD, e.g. the accumulation of aggregated Aβ 42 and the presence of neurofibrillary tangles, are responsible for neuronal loss, but they may also induce death of oligodendrocytes and myelin damage. There is also evidence that myelin pathology may even precede Aβ and tau pathologies in AD. The state of the art does not allow us to determine whether myelin damage is a primary or a secondary injury in AD subjects. The article presents an overview of current knowledge on the role of myelin in AD pathology and its interactions with Aβ and tau pathologies.
Identifiants
pubmed: 32190145
doi: 10.5114/aoms.2018.76863
pii: 33217
pmc: PMC7069444
doi:
Types de publication
Journal Article
Langues
eng
Pagination
345-351Informations de copyright
Copyright: © 2018 Termedia & Banach.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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