Human Tissue Kallikrein 1 Improves Erectile Dysfunction of Streptozotocin-Induced Diabetic Rats by Inhibition of Excessive Oxidative Stress and Activation of the PI3K/AKT/eNOS Pathway.
Animals
Apoptosis
/ drug effects
Blood Glucose
/ metabolism
Body Weight
Calcium
/ metabolism
Cyclic GMP
/ metabolism
Diabetes Mellitus, Experimental
/ complications
Electric Stimulation
Erectile Dysfunction
/ complications
Fasting
/ blood
Fibrosis
Glucose
/ toxicity
Male
Myocytes, Smooth Muscle
/ drug effects
Nitric Oxide Synthase Type III
/ metabolism
Oxidative Stress
/ drug effects
Penis
/ drug effects
Phosphatidylinositol 3-Kinases
/ metabolism
Proto-Oncogene Proteins c-akt
/ metabolism
Rats, Sprague-Dawley
Rats, Transgenic
Signal Transduction
/ drug effects
Streptozocin
Tissue Kallikreins
/ pharmacology
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
12
2019
revised:
02
02
2020
accepted:
08
02
2020
entrez:
20
3
2020
pubmed:
20
3
2020
medline:
11
11
2020
Statut:
epublish
Résumé
To investigate the protective effects and mechanisms of human tissue kallikrein 1 (hKLK1) on type 1 diabetes mellitus- (DM-) induced erectile dysfunction in rats. The hKLK1 preserves erectile function of DM rats through its antitissue excessive OS, apoptosis, and fibrosis effects, as well as activation of the PI3K/AKT/eNOS/cGMP pathway in the penis. Moreover, hKLK1 promotes relaxation and prevents high glucose-induced injuries of CSMC mediated by EC-CSMC crosstalk.
Identifiants
pubmed: 32190176
doi: 10.1155/2020/6834236
pmc: PMC7066404
doi:
Substances chimiques
Blood Glucose
0
Streptozocin
5W494URQ81
Nitric Oxide Synthase Type III
EC 1.14.13.39
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Tissue Kallikreins
EC 3.4.21.35
Cyclic GMP
H2D2X058MU
Glucose
IY9XDZ35W2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6834236Informations de copyright
Copyright © 2020 Yang Luan et al.
Déclaration de conflit d'intérêts
All authors report no conflicts of interest.
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