Primary adrenal leiomyosarcoma: A case report.
adrenal gland
adrenalectomy
leiomyosarcoma
malignant
neoplasia
Journal
Molecular and clinical oncology
ISSN: 2049-9450
Titre abrégé: Mol Clin Oncol
Pays: England
ID NLM: 101613422
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
27
05
2019
accepted:
30
12
2019
entrez:
20
3
2020
pubmed:
20
3
2020
medline:
20
3
2020
Statut:
ppublish
Résumé
Adrenal leiomyosarcomas are rare mesenchymal tumors of the suprarenal region that are usually diagnosed after they have reached a large size. We report the case of a 62-year-old male with an incidentally found left adrenal mass. Magnetic resonance imaging of the retroperitoneal space showed a heterogeneously enhanced mass, measuring 10x8.2 cm, with characteristics suspicious of malignancy. The patient underwent left radical adrenalectomy after the hormonal evaluation of the tumor due to the high probability of adrenocortical carcinoma. However, microscopic examination of the tumor showed a spindle cell sarcoma. Immunohistochemically the neoplastic cells were found positive for desmin and smooth muscle actin and the diagnosis of a well differentiated adrenal leiomyosarcoma was established. During follow-up the patient presented an aggressive course as he developed bone, liver and pulmonary metastases early postoperatively, which were treated with radiation therapy and chemotherapy. The patient has progressive metastatic disease while on chemotherapy 31 months after surgery.
Identifiants
pubmed: 32190312
doi: 10.3892/mco.2020.1987
pii: MCO-0-0-1987
pmc: PMC7057942
doi:
Types de publication
Journal Article
Langues
eng
Pagination
317-320Informations de copyright
Copyright © 2019, Spandidos Publications.
Références
World J Surg Oncol. 2016 Jul 02;14(1):176
pubmed: 27368929
Urology. 2007 Sep;70(3):591.e5-7
pubmed: 17905130
Int J Clin Exp Pathol. 2015 Apr 01;8(4):4258-63
pubmed: 26097622
Arch Pathol Lab Med. 1995 Dec;119(12):1164-7
pubmed: 7503667
J Cancer Res Ther. 2013 Jan-Mar;9(1):114-6
pubmed: 23575089
Case Rep Surg. 2015;2015:702541
pubmed: 25685588
J Ultrasound Med. 2010 Sep;29(9):1369-73
pubmed: 20733196
Case Rep Gastrointest Med. 2018 Oct 3;2018:8196051
pubmed: 30402300
Endocrinol Nutr. 2015 Nov;62(9):472-3
pubmed: 26215892