Combined morphologic and metabolic pipeline for Positron emission tomography/computed tomography based radiotherapy response evaluation in locally advanced pancreatic adenocarcinoma.
Chemoradiotherapy (CRT)
Pancreatic adenocarcinoma (PA)
Positron emission tomography/computed
Radiation therapy (RT)
Treatment response
tomography (PET/CT)
Journal
Physics and imaging in radiation oncology
ISSN: 2405-6316
Titre abrégé: Phys Imaging Radiat Oncol
Pays: Netherlands
ID NLM: 101704276
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
entrez:
20
3
2020
pubmed:
1
1
2019
medline:
1
1
2019
Statut:
ppublish
Résumé
Adaptive radiation planning for pancreatic adenocarcinoma (PA) relies on accurate treatment response assessment, while traditional response evaluation criteria inefficiently characterize tumors with complex morphological features or intrinsically low metabolism. To better assess treatment response of PA, we quantify and compare regional morphological and metabolic features of the 3D pre- and post-radiation therapy (RT) tumor models. Thirty-one PA patients with pre and post-RT Positron emission tomography/computed tomography (PET/CT) scans were evaluated. 3D meshes of pre- and post-RT tumors were generated and registered to establish vertex-wise correspondence. To assess tumor response, Mahalanobis distances ( Among all the imaging/physiological parameters, We introduced a PET/CT-based novel morphologic and metabolic pipeline for response evaluation in locally advanced PA. The fused
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Adaptive radiation planning for pancreatic adenocarcinoma (PA) relies on accurate treatment response assessment, while traditional response evaluation criteria inefficiently characterize tumors with complex morphological features or intrinsically low metabolism. To better assess treatment response of PA, we quantify and compare regional morphological and metabolic features of the 3D pre- and post-radiation therapy (RT) tumor models.
MATERIALS AND METHODS
METHODS
Thirty-one PA patients with pre and post-RT Positron emission tomography/computed tomography (PET/CT) scans were evaluated. 3D meshes of pre- and post-RT tumors were generated and registered to establish vertex-wise correspondence. To assess tumor response, Mahalanobis distances (
RESULTS
RESULTS
Among all the imaging/physiological parameters,
CONCLUSIONS
CONCLUSIONS
We introduced a PET/CT-based novel morphologic and metabolic pipeline for response evaluation in locally advanced PA. The fused
Identifiants
pubmed: 32190750
doi: 10.1016/j.phro.2018.12.003
pmc: PMC7079767
mid: NIHMS1570071
doi:
Types de publication
Journal Article
Langues
eng
Pagination
28-34Subventions
Organisme : NCI NIH HHS
ID : R21 CA234637
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of interest All authors confirm that there are no known conflicts of interest associated with this publication.
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