Using Tenecteplase for Acute Ischemic Stroke: What Is the Hold Up?
Journal
The western journal of emergency medicine
ISSN: 1936-9018
Titre abrégé: West J Emerg Med
Pays: United States
ID NLM: 101476450
Informations de publication
Date de publication:
24 Feb 2020
24 Feb 2020
Historique:
received:
19
09
2019
accepted:
20
01
2020
entrez:
20
3
2020
pubmed:
20
3
2020
medline:
22
9
2020
Statut:
epublish
Résumé
Alteplase is the only Food and Drug Administration-approved intravenous (IV) thrombolytic medication for acute ischemic stroke. However, multiple recent studies comparing tenecteplase and alteplase suggest that tenecteplase is at least as efficacious as alteplase with regards to neurologic improvement. When given at 0.25 milligrams per kilogram (mg/kg), tenecteplase may have less bleeding complications than alteplase as well. This narrative review evaluates the literature and addresses the practical issues with regards to the use of tenecteplase versus alteplase for acute ischemic stroke, and it recommends that physicians consider tenecteplase rather than alteplase for thrombolysis of acute ischemic stroke.
Identifiants
pubmed: 32191176
pii: westjem.2020.1.45279
doi: 10.5811/westjem.2020.1.45279
pmc: PMC7081848
doi:
Substances chimiques
Fibrinolytic Agents
0
Tenecteplase
WGD229O42W
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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