The metabolic disorders associated with chronic consumption of soft and energy drinks in rats.
Animals
Blood Glucose
/ drug effects
Caffeine
/ pharmacology
Carbonated Beverages
/ adverse effects
Cardiovascular Diseases
/ etiology
Energy Drinks
/ adverse effects
Kidney
/ pathology
Lipids
/ blood
Metabolic Diseases
/ chemically induced
Rats
Splenomegaly
/ etiology
Sugars
/ pharmacology
Weight Gain
/ drug effects
Journal
Acta biochimica Polonica
ISSN: 1734-154X
Titre abrégé: Acta Biochim Pol
Pays: Poland
ID NLM: 14520300R
Informations de publication
Date de publication:
19 Mar 2020
19 Mar 2020
Historique:
received:
20
11
2019
accepted:
27
02
2020
pubmed:
20
3
2020
medline:
6
11
2020
entrez:
20
3
2020
Statut:
ppublish
Résumé
Energy Drinks (EDs) and Soft Drinks (SDs) are widely consumed among adolescents and young adults. These drinks contain variable amounts of caffeine which is a central nervous system stimulator; in addition to sugar, taurine, vitamins and herbal extracts. Several adverse effects have been reported for the excessive consumption of caffeine and sugar. This work aimed at providing a comparison between the effect of chronic consumption of both drinks on metabolism biochemically as well as at the histopathological level. Adult albino rats were randomly divided into three groups and treated for 4 weeks. Animals received water (control, group 1), 12.5 ml/kg/day of either Pepsi® (SD, group 2) or Power Horse® (ED, group 3). All animals had free access to water and standard animal chow. ED and SD groups showed a significant weight gain compared to control. ED animals showed a significant increase in serum urea, hyperlipidemia and hyperglycemia in comparison to control and SD groups. Serum uric acid significantly increased in ED and SD groups. ED group showed congestion and inflammation in their renal tissues in addition to splenomegaly and increased phagocyte infiltration. The high caffeine-sugar content in ED exerts a more significant influence on the metabolic pathways than SDs. Both increase the incidence of cardiovascular diseases and tissue inflammation due to their effect on lipid profile and blood glucose. The other ingredients in EDs may play a role in the observed metabolic disturbances. Chronic use of EDs should be especially discouraged to avoid these negative effects.
Sections du résumé
BACKGROUND
BACKGROUND
Energy Drinks (EDs) and Soft Drinks (SDs) are widely consumed among adolescents and young adults. These drinks contain variable amounts of caffeine which is a central nervous system stimulator; in addition to sugar, taurine, vitamins and herbal extracts. Several adverse effects have been reported for the excessive consumption of caffeine and sugar.
AIM
OBJECTIVE
This work aimed at providing a comparison between the effect of chronic consumption of both drinks on metabolism biochemically as well as at the histopathological level.
METHODS
METHODS
Adult albino rats were randomly divided into three groups and treated for 4 weeks. Animals received water (control, group 1), 12.5 ml/kg/day of either Pepsi® (SD, group 2) or Power Horse® (ED, group 3). All animals had free access to water and standard animal chow.
RESULTS
RESULTS
ED and SD groups showed a significant weight gain compared to control. ED animals showed a significant increase in serum urea, hyperlipidemia and hyperglycemia in comparison to control and SD groups. Serum uric acid significantly increased in ED and SD groups. ED group showed congestion and inflammation in their renal tissues in addition to splenomegaly and increased phagocyte infiltration.
CONCLUSION
CONCLUSIONS
The high caffeine-sugar content in ED exerts a more significant influence on the metabolic pathways than SDs. Both increase the incidence of cardiovascular diseases and tissue inflammation due to their effect on lipid profile and blood glucose. The other ingredients in EDs may play a role in the observed metabolic disturbances. Chronic use of EDs should be especially discouraged to avoid these negative effects.
Identifiants
pubmed: 32191411
pii: 2914
doi: 10.18388/abp.2020_2914
doi:
Substances chimiques
Blood Glucose
0
Lipids
0
Sugars
0
Caffeine
3G6A5W338E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM