Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.


Journal

Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034

Informations de publication

Date de publication:
04 2020
Historique:
received: 08 11 2019
revised: 19 01 2020
accepted: 22 01 2020
entrez: 20 3 2020
pubmed: 20 3 2020
medline: 28 11 2020
Statut: ppublish

Résumé

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.

Identifiants

pubmed: 32191849
pii: S1471-4922(20)30016-7
doi: 10.1016/j.pt.2020.01.006
pmc: PMC7083771
mid: NIHMS1571745
pii:
doi:

Substances chimiques

RNA, Mitochondrial 0
RNA, Protozoan 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

337-355

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI091914
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM129041
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI014102
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI064653
Pays : United States
Organisme : NIAID NIH HHS
ID : R15 AI135885
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI061580
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI139448
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI113157
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI101057
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125487
Pays : United States
Organisme : Medical Research Council
ID : MR/L019701/1
Pays : United Kingdom

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Inna Aphasizheva (I)

Department of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA 02118, USA. Electronic address: innaaf@bu.edu.

Juan Alfonzo (J)

Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA.

Jason Carnes (J)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.

Igor Cestari (I)

Institute of Parasitology, McGill University, 21,111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X3V9, Québec, Canada.

Jorge Cruz-Reyes (J)

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.

H Ulrich Göringer (HU)

Department of Molecular Genetics, Darmstadt University of Technology, 64287 Darmstadt, Germany.

Stephen Hajduk (S)

Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.

Julius Lukeš (J)

Institute of Parasitology, Biology Centre, Czech Academy of Sciences and Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic.

Susan Madison-Antenucci (S)

Parasitology Laboratory, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA.

Dmitri A Maslov (DA)

Department of Molecular, Cell, and Systems Biology, University of California - Riverside, Riverside, CA 92521, USA.

Suzanne M McDermott (SM)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.

Torsten Ochsenreiter (T)

Institute of Cell Biology, University of Bern, Baltzerstrasse 4, Bern CH-3012, Switzerland.

Laurie K Read (LK)

Department of Microbiology and Immunology, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA.

Reza Salavati (R)

Institute of Parasitology, McGill University, 21,111 Lakeshore Road, Ste-Anne-de-Bellevue, H9X3V9, Québec, Canada.

Achim Schnaufer (A)

Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3FL, UK.

André Schneider (A)

Department of Chemistry and Biochemistry, University of Bern, Bern CH-3012, Switzerland.

Larry Simpson (L)

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA90095, USA.

Kenneth Stuart (K)

Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA 98109, USA.

Vyacheslav Yurchenko (V)

Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czech Republic; Martsinovsky Institute of Medical Parasitology, Sechenov University, Moscow, Russia.

Z Hong Zhou (ZH)

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA90095, USA.

Alena Zíková (A)

Institute of Parasitology, Biology Centre, Czech Academy of Sciences and Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic.

Liye Zhang (L)

School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.

Sara Zimmer (S)

University of Minnesota Medical School, Duluth campus, Duluth, MN 55812, USA.

Ruslan Aphasizhev (R)

Department of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA 02118, USA.

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