Chimeras of P4-ATPase and Guanylate Cyclase in Pathogenic Protists.
Apicomplexa
P-type ATPase
cGMP signaling
guanylate cyclase
intracellular parasitism
phospholipid translocation
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
11
12
2019
revised:
29
01
2020
accepted:
29
01
2020
entrez:
20
3
2020
pubmed:
20
3
2020
medline:
28
11
2020
Statut:
ppublish
Résumé
Apicomplexan parasites harbor chimeric proteins embodying P4-type ATPase and guanylate cyclase domains. Such proteins - serving as the actuator of cGMP signaling in this group of important pathogens - are indeed unusual in terms of their sheer size, modus operandi, and evolutionary repurposing. Much like the mythological Sphinx, a human-lion chimeric creature that posed challenging riddles, the P4-type ATPase-guanylate cyclase chimeras present both structural and functional conundrums. Here we review the function, topology, mechanism, and intramolecular coordination of the alveolate-specific chimeras in apicomplexan parasites. The steep technological challenge to understand these molecular Sphinxes will surely keep many interdisciplinary researchers busy in the next decades.
Identifiants
pubmed: 32191852
pii: S1471-4922(20)30019-2
doi: 10.1016/j.pt.2020.01.009
pii:
doi:
Substances chimiques
Protozoan Proteins
0
Adenosine Triphosphatases
EC 3.6.1.-
Guanylate Cyclase
EC 4.6.1.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
382-392Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.