Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification.
Animals
Apoptosis
/ drug effects
Calcium
/ metabolism
Cells, Cultured
Gastrin-Releasing Peptide
/ antagonists & inhibitors
Muscle, Smooth, Vascular
/ pathology
Myocytes, Smooth Muscle
/ metabolism
Phosphates
/ metabolism
Rats, Sprague-Dawley
Signal Transduction
/ drug effects
Vascular Calcification
/ genetics
gastrin-releasing peptide
gastrin-releasing peptide receptor
vascular calcification
vascular smooth muscle cells
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
17 03 2020
17 03 2020
Historique:
received:
29
01
2020
revised:
09
03
2020
accepted:
13
03
2020
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Vascular calcification is the pathological deposition of calcium/phosphate in the vascular system and is closely associated with cardiovascular morbidity and mortality. Here, we investigated the role of gastrin-releasing peptide (GRP) in phosphate-induced vascular calcification and its potential regulatory mechanism. We found that the silencing of GRP gene and treatment with the GRP receptor antagonist, RC-3095, attenuated the inorganic phosphate-induced calcification of vascular smooth muscle cells (VSMCs). This attenuation was caused by inhibiting phenotype change, apoptosis and matrix vesicle release in VSMCs. Moreover, the treatment with RC-3095 effectively ameliorated phosphate-induced calcium deposition in rat aortas ex vivo and aortas of chronic kidney disease in mice in vivo. Therefore, the regulation of the GRP-GRP receptor axis may be a potential strategy for treatment of diseases associated with excessive vascular calcification.
Identifiants
pubmed: 32192106
pii: cells9030737
doi: 10.3390/cells9030737
pmc: PMC7140688
pii:
doi:
Substances chimiques
Phosphates
0
Gastrin-Releasing Peptide
80043-53-4
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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