Strategies for smoking cessation (pharmacologic intervention versus enhanced motivation vs. standard motivation) in TB patients under treatment in the RNTCP, India - A cluster - Randomized trial.
Bupropion
Cessation
Enhanced counselling
Smoking
Tuberculosis
Journal
The Indian journal of tuberculosis
ISSN: 0019-5707
Titre abrégé: Indian J Tuberc
Pays: India
ID NLM: 0373027
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
02
08
2019
revised:
16
10
2019
accepted:
09
01
2020
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
5
1
2021
Statut:
ppublish
Résumé
Tuberculosis burden is still high and smoking prevalence among males has increased in India. It is found that increased morbidity, mortality and relapse among TB smokers. Setting: Patients from two Revised National Tuberculosis Control Program Centres of Tamilnadu form the study population. To compare the effectiveness of Bupropion therapy along with standard counselling versus enhanced counseling versus standard counseling for smoking cessation among TB patients. Cluster randomized effectiveness trial. Patients from each of the thirty-six Designated Microscopic Centres were randomly allocated to receive one of the three interventions using cluster randomization. Smoking cessation was assessed by self-reporting and confirmed by Carbon monoxide(CO) monitors, done at three-time points and TB treatment outcome at the end of ATT. Out of 517 male patients enrolled to the study, the smoking status is available only to 381 subjects. The proportion of patients who have quit smoking in drug, enhanced and standard arms at the end of treatment was 67%, 83% and 52% (P= < 0.001). There was no statistical significance in response to TB treatment between those who quit and those who did not (Favourable response 99.2% vs 97.6%). Both enhanced counselling arm and drug arm are effective strategies for smoking cessation among TB patients and their implementation in the TB programs are recommended.
Sections du résumé
BACKGROUND
BACKGROUND
Tuberculosis burden is still high and smoking prevalence among males has increased in India. It is found that increased morbidity, mortality and relapse among TB smokers.
METHOD
METHODS
Setting: Patients from two Revised National Tuberculosis Control Program Centres of Tamilnadu form the study population.
OBJECTIVE
OBJECTIVE
To compare the effectiveness of Bupropion therapy along with standard counselling versus enhanced counseling versus standard counseling for smoking cessation among TB patients.
STUDY DESIGN
METHODS
Cluster randomized effectiveness trial.
PROCEDURE
METHODS
Patients from each of the thirty-six Designated Microscopic Centres were randomly allocated to receive one of the three interventions using cluster randomization. Smoking cessation was assessed by self-reporting and confirmed by Carbon monoxide(CO) monitors, done at three-time points and TB treatment outcome at the end of ATT.
RESULTS
RESULTS
Out of 517 male patients enrolled to the study, the smoking status is available only to 381 subjects. The proportion of patients who have quit smoking in drug, enhanced and standard arms at the end of treatment was 67%, 83% and 52% (P= < 0.001). There was no statistical significance in response to TB treatment between those who quit and those who did not (Favourable response 99.2% vs 97.6%).
CONCLUSION
CONCLUSIONS
Both enhanced counselling arm and drug arm are effective strategies for smoking cessation among TB patients and their implementation in the TB programs are recommended.
Identifiants
pubmed: 32192623
pii: S0019-5707(20)30006-8
doi: 10.1016/j.ijtb.2020.01.006
pii:
doi:
Substances chimiques
Antitubercular Agents
0
Smoking Cessation Agents
0
Bupropion
01ZG3TPX31
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
8-14Informations de copyright
Copyright © 2020 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved.