Individualized perturbation of the human connectome reveals reproducible biomarkers of network dynamics relevant to cognition.
TMS-EEG
cognition
fMRI
resting-state networks
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
07 04 2020
07 04 2020
Historique:
pubmed:
21
3
2020
medline:
21
7
2020
entrez:
21
3
2020
Statut:
ppublish
Résumé
Large-scale brain networks are often described using resting-state functional magnetic resonance imaging (fMRI). However, the blood oxygenation level-dependent (BOLD) signal provides an indirect measure of neuronal firing and reflects slow-evolving hemodynamic activity that fails to capture the faster timescale of normal physiological function. Here we used fMRI-guided transcranial magnetic stimulation (TMS) and simultaneous electroencephalography (EEG) to characterize individual brain dynamics within discrete brain networks at high temporal resolution. TMS was used to induce controlled perturbations to individually defined nodes of the default mode network (DMN) and the dorsal attention network (DAN). Source-level EEG propagation patterns were network-specific and highly reproducible across sessions 1 month apart. Additionally, individual differences in high-order cognitive abilities were significantly correlated with the specificity of TMS propagation patterns across DAN and DMN, but not with resting-state EEG dynamics. Findings illustrate the potential of TMS-EEG perturbation-based biomarkers to characterize network-level individual brain dynamics at high temporal resolution, and potentially provide further insight on their behavioral significance.
Identifiants
pubmed: 32193345
pii: 1911240117
doi: 10.1073/pnas.1911240117
pmc: PMC7149310
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
8115-8125Subventions
Organisme : NINDS NIH HHS
ID : R21 NS085491
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS082870
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD069776
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117063
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025758
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060981
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115949
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113929
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073601
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060987
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031720
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH099196
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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