Longitudinal phenotype development in a minipig model of neurofibromatosis type 1.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
19 03 2020
Historique:
received: 16 10 2019
accepted: 17 02 2020
entrez: 21 3 2020
pubmed: 21 3 2020
medline: 15 12 2020
Statut: epublish

Résumé

Neurofibromatosis type 1 (NF1) is a rare, autosomal dominant disease with variable clinical presentations. Large animal models are useful to help dissect molecular mechanisms, determine relevant biomarkers, and develop effective therapeutics. Here, we studied a NF1 minipig model (NF1

Identifiants

pubmed: 32193437
doi: 10.1038/s41598-020-61251-4
pii: 10.1038/s41598-020-61251-4
pmc: PMC7081358
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

5046

Subventions

Organisme : NCI NIH HHS
ID : P30 CA086862
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005605
Pays : United States
Organisme : NIH HHS
ID : S10 OD018526
Pays : United States

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Auteurs

Johanna Uthoff (J)

Department of Radiology, University of Iowa, Iowa City, IA, USA.
Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.

Jared Larson (J)

Department of Radiology, University of Iowa, Iowa City, IA, USA.

Takashi S Sato (TS)

Department of Radiology, University of Iowa, Iowa City, IA, USA.

Emily Hammond (E)

Department of Radiology, University of Iowa, Iowa City, IA, USA.
Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.

Kimberly E Schroeder (KE)

Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.

Frank Rohret (F)

Exemplar Genetics, Coralville, IA, USA.

Christopher S Rogers (CS)

Exemplar Genetics, Coralville, IA, USA.

Dawn E Quelle (DE)

Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
Department of Pharmacology, University of Iowa, Iowa City, IA, USA.

Benjamin W Darbro (BW)

Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
Department of Pediatrics, University of Iowa, Iowa City, IA, USA.

Rajesh Khanna (R)

Department of Pharmacology, University of Arizona, Tucson, AZ, USA.

Jill M Weimer (JM)

Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA.

David K Meyerholz (DK)

Department of Pathology, University of Iowa, Iowa City, IA, USA.

Jessica C Sieren (JC)

Department of Radiology, University of Iowa, Iowa City, IA, USA. jessica-sieren@uiowa.edu.
Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA. jessica-sieren@uiowa.edu.
Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA. jessica-sieren@uiowa.edu.

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