Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 03 2020
19 03 2020
Historique:
received:
14
11
2019
accepted:
04
03
2020
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Therapeutic success of B cell-targeting approaches in multiple sclerosis (MS) has intensified research into the pathogenic and regulatory roles these cells play in demyelinating disease. Dissecting the function of B cells in the MS mouse model experimental autoimmune encephalomyelitis (EAE) is largely confined to induction with either the myelin oligodendrocyte glycoprotein epitope MOG
Identifiants
pubmed: 32193439
doi: 10.1038/s41598-020-61928-w
pii: 10.1038/s41598-020-61928-w
pmc: PMC7081236
doi:
Substances chimiques
Epitopes
0
Mog protein, mouse
0
Myelin Proteolipid Protein
0
Myelin-Oligodendrocyte Glycoprotein
0
Peptide Fragments
0
myelin proteolipid protein (178-191)
172228-98-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5011Subventions
Organisme : BLRD VA
ID : I01 BX003677
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121567
Pays : United States
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