HYPHYCA: a prospective study in 613 patients conducting a comprehensive analysis for predictive factors of physiological
18F-FDG
Anal cancer
PET
Physiological uptake
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
20 Mar 2020
20 Mar 2020
Historique:
received:
17
12
2019
accepted:
25
02
2020
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
21
3
2020
Statut:
epublish
Résumé
Anal cancer is a relatively rare tumor of which incidence increases in developed countries. Over a 2-month period, patients aged 18 years old and more, referred for Six hundred and thirteen patients were included (sex ratio F/M = 0.99) and 545 (89%) questionnaires were entirely completed. Significantly more males presented anal canal hypermetabolism (sex ratio (M/F) = 1.18 versus 0.85, p = 0.048). Moreover, patients with anal canal hypermetabolism had higher BMI (27.6 (5.7) kg/m According to our study, the predictive factors of physiological anal canal hypermetabolism are high BMI, male gender, hemorrhoid history, and rectum filled with only feces. This may pave the way to a more specific interpretation of post radio-chemotherapy PET evaluations of anal canal cancer, provided that other studies are conducted in this specific population. This prospective study was registered at Clinicaltrial.gov: NCT03506529; HYPHYCA on April 24, 2018.
Sections du résumé
BACKGROUND
BACKGROUND
Anal cancer is a relatively rare tumor of which incidence increases in developed countries.
MATERIALS AND METHODS
METHODS
Over a 2-month period, patients aged 18 years old and more, referred for
RESULTS
RESULTS
Six hundred and thirteen patients were included (sex ratio F/M = 0.99) and 545 (89%) questionnaires were entirely completed. Significantly more males presented anal canal hypermetabolism (sex ratio (M/F) = 1.18 versus 0.85, p = 0.048). Moreover, patients with anal canal hypermetabolism had higher BMI (27.6 (5.7) kg/m
CONCLUSION
CONCLUSIONS
According to our study, the predictive factors of physiological anal canal hypermetabolism are high BMI, male gender, hemorrhoid history, and rectum filled with only feces. This may pave the way to a more specific interpretation of post radio-chemotherapy PET evaluations of anal canal cancer, provided that other studies are conducted in this specific population.
TRIAL REGISTRATION
BACKGROUND
This prospective study was registered at Clinicaltrial.gov: NCT03506529; HYPHYCA on April 24, 2018.
Identifiants
pubmed: 32193623
doi: 10.1186/s13550-020-0615-5
pii: 10.1186/s13550-020-0615-5
pmc: PMC7082447
doi:
Banques de données
ClinicalTrials.gov
['NCT03506529']
Types de publication
Journal Article
Langues
eng
Pagination
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