Tumor-associated macrophages regulate gastric cancer cell invasion and metastasis through TGFβ2/NF-κB/Kindlin-2 axis.
Gastric cancer
Kindlin-2
invasion and metastasis
tumor-associated macrophage
Journal
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
ISSN: 1000-9604
Titre abrégé: Chin J Cancer Res
Pays: China
ID NLM: 9315242
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
21
3
2020
Statut:
ppublish
Résumé
Recent studies have shown that tumor-associated macrophages (TAMs) play an important role in cancer invasion and metastasis. Our previous studies have reported that TAMs promote the invasion and metastasis of gastric cancer (GC) cells through the Kindlin-2 pathway. However, the mechanism needs to be clarified. THP-1 monocytes were induced by PMA/interleukin (IL)-4/IL-13 to establish an efficient TAM model We found that Kindlin-2 expression was upregulated at both mRNA and protein levels in GC cells cocultured with TAMs, associated with higher invasion rate. Kindlin-2 knockdown reduced the invasion rate of GC cells under coculture condition. TGFβ2 secreted by TAMs regulated the expression of Kindlin-2 through the transcription factor NF-кB. TAMs thus participated in the progression of GC through the TGFβ2/NF-κB/Kindlin-2 axis. Kindlin-2 expression and TAM infiltration were significantly positively correlated with TNM stage, and patients with high Kindlin-2 expression had significantly poorer overall survival than patients with low Kindlin-2 expression. Furthermore, Kindlin-2 promoted the invasion of GC cells This study elucidates the mechanism of TAMs participating in GC cell invasion and metastasis through the TGFβ2/NF-κB/Kindlin-2 axis, providing a possibility for new treatment options and approaches.
Identifiants
pubmed: 32194307
doi: 10.21147/j.issn.1000-9604.2020.01.09
pii: cjcr-32-1-72
pmc: PMC7072013
doi:
Types de publication
Journal Article
Langues
eng
Pagination
72-88Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2020 Chinese Journal of Cancer Research. All rights reserved.
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