The Genetic Landscape of Dystrophin Mutations in Italy: A Nationwide Study.

dystrophin exon skipping therapy muscular dystrophy nationwide study read-through therapy

Journal

Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621

Informations de publication

Date de publication:
2020
Historique:
received: 13 09 2019
accepted: 03 02 2020
entrez: 21 3 2020
pubmed: 21 3 2020
medline: 21 3 2020
Statut: epublish

Résumé

Dystrophinopathies are inherited diseases caused by mutations in the dystrophin (

Identifiants

pubmed: 32194622
doi: 10.3389/fgene.2020.00131
pmc: PMC7063120
doi:

Types de publication

Journal Article

Langues

eng

Pagination

131

Informations de copyright

Copyright © 2020 Neri, Rossi, Trabanelli, Mauro, Selvatici, Falzarano, Spedicato, Margutti, Rimessi, Fortunato, Fabris, Gualandi, Comi, Tedeschi, Seia, Fiorillo, Traverso, Bruno, Giardina, Piemontese, Merla, Cau, Marica, Scuderi, Borgione, Tessa, Astrea, Santorelli, Merlini, Mora, Bernasconi, Gibertini, Sansone, Mongini, Berardinelli, Pini, Liguori, Filosto, Messina, Vita, Toscano, Vita, Pane, Servidei, Pegoraro, Bello, Travaglini, Bertini, D'Amico, Ergoli, Politano, Torella, Nigro, Mercuri and Ferlini.

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Auteurs

Marcella Neri (M)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Rachele Rossi (R)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Cecilia Trabanelli (C)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Antonio Mauro (A)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Rita Selvatici (R)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Maria Sofia Falzarano (MS)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Noemi Spedicato (N)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Alice Margutti (A)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Paola Rimessi (P)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Fernanda Fortunato (F)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Marina Fabris (M)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Francesca Gualandi (F)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Giacomo Comi (G)

Neuroscience Section, Department of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, Milan, Italy.

Silvana Tedeschi (S)

Laboratory of Medical Genetics, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Manuela Seia (M)

Laboratory of Medical Genetics, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Chiara Fiorillo (C)

Paediatric Neurology and Muscular Diseases Unit, University of Genoa and G. Gaslini Institute, Genoa, Italy.

Monica Traverso (M)

Paediatric Neurology and Muscular Diseases Unit, University of Genoa and G. Gaslini Institute, Genoa, Italy.

Claudio Bruno (C)

Center of Translational and Experimental Myology, IRCCS Gaslini, Genova, Italy.

Emiliano Giardina (E)

Molecular Genetics Laboratory UILDM, Santa Lucia Foundation, Rome, Italy.

Maria Rosaria Piemontese (MR)

Division of Medical Genetics, IRCCS Casa Sollievo della Sofferenza, Foggia, Italy.

Giuseppe Merla (G)

Division of Medical Genetics, IRCCS Casa Sollievo della Sofferenza, Foggia, Italy.

Milena Cau (M)

Laboratory of Genetics and Genomics, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Monica Marica (M)

Clinica Pediatrica e Malattie Rare, Brotzu, Cagliari, Italy.

Carmela Scuderi (C)

Unit of Neuromuscular Diseases, Oasi Research Institute-IRCCS, Troina, Italy.

Eugenia Borgione (E)

Unit of Neuromuscular Diseases, Oasi Research Institute-IRCCS, Troina, Italy.

Alessandra Tessa (A)

Department of Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa, Italy.

Guia Astrea (G)

Department of Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa, Italy.

Filippo Maria Santorelli (FM)

Department of Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa, Italy.

Luciano Merlini (L)

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Marina Mora (M)

Neuromuscular Diseases and Neuroimmunology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Pia Bernasconi (P)

Neuromuscular Diseases and Neuroimmunology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Sara Gibertini (S)

Neuromuscular Diseases and Neuroimmunology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Valeria Sansone (V)

Neurorehabilitation Unit, Department Biomedical Sciences for Health, University of Milan, Milan, Italy.

Tiziana Mongini (T)

Neuromuscular Center, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy.

Angela Berardinelli (A)

Child Neurology and Psychiatry Unit, "Casimiro Mondino" Foundation, Pavia, Italy.

Antonella Pini (A)

Child Neurology Unit, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.

Rocco Liguori (R)

Department of Biomedical and Neuro Motor Sciences, University of Bologna, Bologna, Italy.

Massimiliano Filosto (M)

Laboratory of Medical Genetics, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Sonia Messina (S)

Department of Clinical and Experimental Medicine, University of Messina and Nemo Sud Clinical Center, Messina, Italy.

Gianluca Vita (G)

Department of Clinical and Experimental Medicine, University of Messina and Nemo Sud Clinical Center, Messina, Italy.

Antonio Toscano (A)

Department of Clinical and Experimental Medicine, University of Messina and Nemo Sud Clinical Center, Messina, Italy.

Giuseppe Vita (G)

Department of Clinical and Experimental Medicine, University of Messina and Nemo Sud Clinical Center, Messina, Italy.

Marika Pane (M)

Centro Clinico Nemo, Policlinico A. Gemelli, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Serenella Servidei (S)

UOC Neurofisiopatologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy.

Elena Pegoraro (E)

Department of Neurosciences, University of Padua, Padua, Italy.

Luca Bello (L)

Department of Neurosciences, University of Padua, Padua, Italy.

Lorena Travaglini (L)

Unit of Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, Bambino Gesu Children's Research Hospital IRCCS, Rome, Italy.

Enrico Bertini (E)

Unit of Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, Bambino Gesu Children's Research Hospital IRCCS, Rome, Italy.

Adele D'Amico (A)

Unit of Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, Bambino Gesu Children's Research Hospital IRCCS, Rome, Italy.

Manuela Ergoli (M)

Cardiomiology and Medical Genetics, University of Campania "Luigi Vanvitelli, Naples, Italy.

Luisa Politano (L)

Cardiomiology and Medical Genetics, University of Campania "Luigi Vanvitelli, Naples, Italy.

Annalaura Torella (A)

Department of Precision Medicine, University of Campania "Luigi Vanvitelli, Naples, Italy.

Vincenzo Nigro (V)

Department of Precision Medicine, University of Campania "Luigi Vanvitelli, Naples, Italy.

Eugenio Mercuri (E)

Centro Clinico Nemo, Policlinico A. Gemelli, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Pediatric Neurology, Catholic University, Rome, Italy.

Alessandra Ferlini (A)

Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Dubowitz Neuromuscular Unit, Institute of Child Health, University College London, London, United Kingdom.

Classifications MeSH