Multiscale modelling of drug transport and metabolism in liver spheroids.
drug transport
hepatocytes
mathematical modelling
organoid
spheroid
systems pharmacology
Journal
Interface focus
ISSN: 2042-8898
Titre abrégé: Interface Focus
Pays: England
ID NLM: 101531990
Informations de publication
Date de publication:
06 Apr 2020
06 Apr 2020
Historique:
accepted:
13
11
2019
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
21
3
2020
Statut:
ppublish
Résumé
In early preclinical drug development, potential candidates are tested in the laboratory using isolated cells. These
Identifiants
pubmed: 32194929
doi: 10.1098/rsfs.2019.0041
pii: rsfs20190041
pmc: PMC7061947
doi:
Banques de données
figshare
['10.6084/m9.figshare.c.4747547']
Types de publication
Journal Article
Langues
eng
Pagination
20190041Subventions
Organisme : Medical Research Council
ID : MR/R025762/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019332/1
Pays : United Kingdom
Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
We declare we have no competing interests.
Références
Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):234-238
pubmed: 28470941
SLAS Discov. 2018 Jul;23(6):561-573
pubmed: 29466676
AAPS J. 2013 Jul;15(3):816-31
pubmed: 23605950
Biotechnol Bioeng. 2008 Oct 1;101(2):388-99
pubmed: 18500767
Nat Rev Drug Discov. 2010 Aug;9(8):597-614
pubmed: 20671764
J R Soc Interface. 2018 Jan;15(138):
pubmed: 29367239
Chem Res Toxicol. 2014 Mar 17;27(3):314-29
pubmed: 24446777
Front Bioeng Biotechnol. 2019 Feb 18;7:17
pubmed: 30834246
Clin Pharmacol Ther. 2017 Jan;101(1):121-129
pubmed: 27804130
Toxicol Sci. 2018 Apr 1;162(2):655-666
pubmed: 29329425
Nat Med. 2019 May;25(5):838-849
pubmed: 31011202
Sci Rep. 2016 Oct 19;6:35434
pubmed: 27759057
Front Physiol. 2016 Nov 25;7:551
pubmed: 27932987
Arch Toxicol. 2018 Feb;92(2):557-569
pubmed: 29362863
J Pharmacol Exp Ther. 2012 Apr;341(1):2-15
pubmed: 22190645
CPT Pharmacometrics Syst Pharmacol. 2014 Oct 22;3:e142
pubmed: 25338195
Biomed Opt Express. 2014 Sep 29;5(10):3730-8
pubmed: 25360385
J Oral Maxillofac Pathol. 2014 Sep;18(Suppl 1):S111-6
pubmed: 25364159
Int J Mol Sci. 2018 Jan 18;19(1):
pubmed: 29346265
SLAS Discov. 2017 Jun;22(5):456-472
pubmed: 28520521
Sci Rep. 2016 May 04;6:25187
pubmed: 27143246
Adv Drug Deliv Rev. 2012 Jan;64(1):29-39
pubmed: 21569804
Drug Metab Dispos. 2012 Sep;40(9):1744-56
pubmed: 22665271
Trends Pharmacol Sci. 2015 Jan;36(1):15-21
pubmed: 25458537
Nat Rev Drug Discov. 2015 Jan;14(1):29-44
pubmed: 25475361
Wiley Interdiscip Rev Syst Biol Med. 2015 Jul-Aug;7(4):221-41
pubmed: 25950758
Drug Metab Dispos. 2007 Feb;35(2):293-301
pubmed: 17132764
Nat Rev Drug Discov. 2008 Mar;7(3):205-20
pubmed: 18309312
Wiley Interdiscip Rev Comput Mol Sci. 2016 Mar;6(2):147-172
pubmed: 27066112
Toxicol In Vitro. 2019 Mar;55:160-172
pubmed: 30578835
Biotechnol Bioeng. 2002 Mar 5;77(5):495-516
pubmed: 11788949
J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):51-138
pubmed: 20574894
Toxicol Res (Camb). 2013 Jan 1;2(1):40-59
pubmed: 26966512
Toxicol In Vitro. 2018 Apr;48:262-275
pubmed: 29408671
Proc Math Phys Eng Sci. 2019 May;475(2225):20180647
pubmed: 31236040