Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk.
Sap97
arrhythmia
ion channels
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
pubmed:
21
3
2020
medline:
14
7
2020
entrez:
21
3
2020
Statut:
ppublish
Résumé
Synapse-associated protein 97 (SAP97) is a scaffolding protein crucial for the functional expression of several cardiac ion channels and therefore proper cardiac excitability. Alterations in the functional expression of SAP97 can modify the ionic currents underlying the cardiac action potential and consequently confer susceptibility for arrhythmogenesis. In this study, we generated a murine model for inducible, cardiac-targeted Sap97 ablation to investigate arrhythmia susceptibility and the underlying molecular mechanisms. Furthermore, we sought to identify human SAP97 (
Identifiants
pubmed: 32196358
doi: 10.1152/ajpheart.00481.2019
pmc: PMC7311695
doi:
Substances chimiques
Discs Large Homolog 1 Protein
0
Dlg1 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
H1357-H1370Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL152201
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124319
Pays : United States
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