Age-related differences in blood pressure, ultrasound-derived arterial diameters and arterial wall stiffness parameters in horses.
compliance
distensibility
horse
pulse wave velocity
vascular
Journal
Equine veterinary journal
ISSN: 2042-3306
Titre abrégé: Equine Vet J
Pays: United States
ID NLM: 0173320
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
06
01
2020
revised:
06
03
2020
accepted:
14
03
2020
pubmed:
21
3
2020
medline:
8
10
2020
entrez:
21
3
2020
Statut:
ppublish
Résumé
Arterial rupture mainly affects older horses. The reason why older horses are more prone to arterial rupture and which underlying vascular changes predispose older horses to aortic rupture is still unclear. To investigate the effect of ageing on the equine arterial wall and blood pressure. Cohort study. Non-invasive blood pressure measurement using a tail cuff and vascular ultrasound from aorta, common carotid artery and external iliac artery was performed in 50 healthy young (3-7 years) and 50 healthy old Warmblood horses (>18 years). Arterial diameters and cross-sectional areas, and arterial wall thickness were measured offline. Regional arterial wall stiffness of the aorta and common carotid artery were assessed using pulse wave velocity, while lumen area/diameter change, strain, compliance and distensibility were calculated to assess local arterial wall stiffness. No difference in blood pressure was found between old and young horses. All arterial dimensions and intima-media thickness of the common carotid artery were significantly larger in old horses. A significantly higher local arterial wall stiffness was found for the aorta and the caudal common carotid artery in older horses. For the external iliac artery, no significant differences in arterial wall stiffness were found. Both aortic and carotid pulse wave velocities were higher in older horses compared with younger horses. Blood pressure was measured non-invasively. In horses, arteries stiffen with age, in combination with luminal enlargement and arterial wall thickening. This might, at least partially, explain the increased incidence of arterial rupture in older horses.
Sections du résumé
BACKGROUND
BACKGROUND
Arterial rupture mainly affects older horses. The reason why older horses are more prone to arterial rupture and which underlying vascular changes predispose older horses to aortic rupture is still unclear.
OBJECTIVES
OBJECTIVE
To investigate the effect of ageing on the equine arterial wall and blood pressure.
STUDY DESIGN
METHODS
Cohort study.
METHODS
METHODS
Non-invasive blood pressure measurement using a tail cuff and vascular ultrasound from aorta, common carotid artery and external iliac artery was performed in 50 healthy young (3-7 years) and 50 healthy old Warmblood horses (>18 years). Arterial diameters and cross-sectional areas, and arterial wall thickness were measured offline. Regional arterial wall stiffness of the aorta and common carotid artery were assessed using pulse wave velocity, while lumen area/diameter change, strain, compliance and distensibility were calculated to assess local arterial wall stiffness.
RESULTS
RESULTS
No difference in blood pressure was found between old and young horses. All arterial dimensions and intima-media thickness of the common carotid artery were significantly larger in old horses. A significantly higher local arterial wall stiffness was found for the aorta and the caudal common carotid artery in older horses. For the external iliac artery, no significant differences in arterial wall stiffness were found. Both aortic and carotid pulse wave velocities were higher in older horses compared with younger horses.
MAIN LIMITATIONS
CONCLUSIONS
Blood pressure was measured non-invasively.
CONCLUSIONS
CONCLUSIONS
In horses, arteries stiffen with age, in combination with luminal enlargement and arterial wall thickening. This might, at least partially, explain the increased incidence of arterial rupture in older horses.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
868-875Subventions
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1134917N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1S56217N
Informations de copyright
© 2020 EVJ Ltd.
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