Progesterone decreases apnoea and reduces oxidative stress induced by chronic intermittent hypoxia in ovariectomized female rats.
intermittent hypoxia
oxidative stress
progesterone
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
14
01
2020
accepted:
12
03
2020
pubmed:
21
3
2020
medline:
9
9
2021
entrez:
21
3
2020
Statut:
ppublish
Résumé
What is the central question of this study? Does progesterone reduce the effect of chronic intermittent hypoxia (CIH) on arterial blood pressure, respiratory control and oxidative stress in the central nervous system in ovariectomized rats? What is the main finding and its importance? Progesterone does not prevent the elevation of arterial blood pressure in rats exposed to CIH, but normalizes respiratory control, and reduces cerebral oxidative stress. This study draws focus to a potential role of progesterone and the consequences of sleep apnoea in menopausal women. We tested the hypothesis that progesterone (Prog) reduces the effect of chronic intermittent hypoxia (CIH) on arterial blood pressure, respiratory chemoreflexes and oxidative stress in the central nervous system. Ovariectomized female rats were implanted with osmotic pumps delivering vehicle (Veh) or Prog (4 mg kg
Substances chimiques
Antioxidants
0
Progesterone
4G7DS2Q64Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1025-1034Subventions
Organisme : CIHR
ID : MOP‐102715
Pays : Canada
Organisme : CIHR
ID : MOP‐102715
Pays : Canada
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.
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