Comparison of the incidence of diabetes in United States and Indian youth: An international harmonization of youth diabetes registries.
India
United States
descriptive epidemiology of diabetes
diabetes in youth; incidence
Journal
Pediatric diabetes
ISSN: 1399-5448
Titre abrégé: Pediatr Diabetes
Pays: Denmark
ID NLM: 100939345
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
10
06
2019
revised:
22
01
2020
accepted:
12
02
2020
pubmed:
21
3
2020
medline:
18
11
2021
entrez:
21
3
2020
Statut:
ppublish
Résumé
Incidence of youth-onset diabetes in India has not been well described. Comparison of incidence, across diabetes registries, has the potential to inform hypotheses for risk factors. We sought to compare the incidence of diabetes in the U.S.-based registry of youth onset diabetes (SEARCH) to the Registry of Diabetes with Young Age at Onset (YDR-Chennai and New Delhi regions) in India. We harmonized data from both SEARCH and YDR to the Observational Medical Outcomes Partnership (OMOP) Common Data Model. Data were from youth registered with incident diabetes (2006-2012). Denominators were from census and membership data. We calculated diabetes incidence by averaging the total cases across the entire follow-up period and dividing this by the estimated census population corresponding to the source population for case ascertainment. Incidence was calculated for each of the registries and compared by type and within age and sex categories using a 2-sided, skew-corrected inverted score test. Incidence of type 1 was higher in SEARCH (21.2 cases/100 000 [95% CI: 19.9, 22.5]) than YDR (4.9 cases/100 000 [95% CI: 4.3, 5.6]). Incidence of type 2 diabetes was also higher in SEARCH (5.9 cases/100 000 [95% CI: 5.3, 6.6] in SEARCH vs 0.5/cases/100 000 [95% CI: 0.3, 0.7] in YDR). The age distribution of incident type 1 diabetes cases was similar across registries, whereas type 2 diabetes incidence was higher at an earlier age in SEARCH. Sex differences existed in SEARCH only, with a higher rate of type 2 diabetes among females. The incidence of youth-onset type 1 and 2 diabetes was significantly different between registries. Additional data are needed to elucidate whether the differences observed represent diagnostic delay, differences in genetic susceptibility, or differences in distribution of risk factors.
Identifiants
pubmed: 32196874
doi: 10.1111/pedi.13009
pmc: PMC7748376
mid: NIHMS1648766
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
8-14Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK057516
Pays : United States
Organisme : ACL HHS
ID : U18DP006139
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U01 DP000247
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U18 DP002710
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U18 DP006138
Pays : United States
Organisme : ACL HHS
ID : U18DP006138
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000154
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U18 DP002714
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U01 DP000248
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U01 DP000244
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000062
Pays : United States
Organisme : ACL HHS
ID : U18DP006134
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U18 DP002709
Pays : United States
Organisme : ACL HHS
ID : U18DP006131
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000077
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK108173
Pays : United States
Organisme : CDC HHS
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK105869
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001425
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK127208
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000423
Pays : United States
Organisme : ACL HHS
ID : U18DP006136
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U01 DP000250
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U01 DP000246
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U01 DP000254
Pays : United States
Organisme : ACL HHS
ID : U18DP006133
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U18 DP002708
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21DK105869-02
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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