Erythropoietin induces miRNA-210 by JAK2/STAT5 signaling in PBMCs of End-stage Renal Disease patients.
Aged
Anemia
/ drug therapy
Erythropoietin
/ pharmacology
Female
Humans
Janus Kinase 2
/ genetics
Kidney Failure, Chronic
/ pathology
Leukocytes, Mononuclear
/ drug effects
Male
MicroRNAs
/ blood
Recombinant Proteins
/ pharmacology
Renal Dialysis
/ adverse effects
STAT5 Transcription Factor
/ genetics
JAK2
PBMCs
STAT5
anemia
erythropoietin
miRNA-210
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
17
08
2019
revised:
03
02
2020
accepted:
17
03
2020
pubmed:
21
3
2020
medline:
25
5
2021
entrez:
21
3
2020
Statut:
ppublish
Résumé
Anemia of chronic kidney disease is associated with blunted response/resistance to erythropoietin-stimulating agents (ESAs) in hemodialysis (HD) patients. Several molecules have been successfully associated with ESA responsiveness; however, none of them is now considered a valid therapeutic biomarker of erythropoietin resistance in these patients. We performed an evaluation of the level of specific plasma circulating miRNAs in blood samples of HD patients, in relation to ESA treatment, with a follow-up of 1 year (T0-T3). We found significantly lower circulating levels of all miRNAs analyzed at baseline (T0) in HD patients vs. healthy control (HC). The plasmatic levels of miRNA-210 resulted significantly and negatively associated with Erythropoietin Resistance Index (ERI), and the variance of ΔmiRNA-210 (miRNA-210
Substances chimiques
MIRN210 microRNA, human
0
MicroRNAs
0
Recombinant Proteins
0
STAT5 Transcription Factor
0
Erythropoietin
11096-26-7
JAK2 protein, human
EC 2.7.10.2
Janus Kinase 2
EC 2.7.10.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5167-5182Informations de copyright
© 2020 Federation of European Biochemical Societies.
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