In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren.
Blood Proteins
/ metabolism
Cytochrome P-450 Enzyme System
/ metabolism
Enzyme Induction
Glucuronides
/ metabolism
Glucuronosyltransferase
/ genetics
Humans
Intestines
Kidney
Kinetics
Liver
Microsomes
/ metabolism
Oxadiazoles
/ pharmacology
Phenotype
Protein Binding
Recombinant Proteins
/ metabolism
CYP Inhibition and CYP Induction
Enzyme Kinetics
In vitro Metabolism
Reaction Phenotyping
UGT
Journal
Pharmacology research & perspectives
ISSN: 2052-1707
Titre abrégé: Pharmacol Res Perspect
Pays: United States
ID NLM: 101626369
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
24
01
2020
revised:
24
02
2020
accepted:
24
02
2020
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
7
4
2021
Statut:
ppublish
Résumé
Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potential with CYP enzymes. Incubation of [
Identifiants
pubmed: 32196986
doi: 10.1002/prp2.576
pmc: PMC7083565
doi:
Substances chimiques
Blood Proteins
0
Glucuronides
0
Oxadiazoles
0
Recombinant Proteins
0
Cytochrome P-450 Enzyme System
9035-51-2
Glucuronosyltransferase
EC 2.4.1.17
ataluren
K16AME9I3V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e00576Informations de copyright
© 2020 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.
Références
FASEB J. 2014 Apr;28(4):1593-9
pubmed: 24371125
Lancet Neurol. 2010 Jan;9(1):77-93
pubmed: 19945913
Lancet Respir Med. 2014 Jul;2(7):539-47
pubmed: 24836205
Am J Respir Crit Care Med. 2018 Oct 15;198(8):1099-1102
pubmed: 30011228
Muscle Nerve. 2014 Oct;50(4):477-87
pubmed: 25042182
Pharmacol Res Perspect. 2020 Apr;8(2):e00576
pubmed: 32196986
Drug Metab Dispos. 2008 Jun;36(6):1056-62
pubmed: 18362158
Muscle Nerve. 2010 Jun;41(6):740-5
pubmed: 20373504
Drug Metab Dispos. 2009 Jan;37(1):32-40
pubmed: 18838504
Eur J Med Chem. 2018 Nov 5;159:126-142
pubmed: 30278331
J Clin Pharmacol. 2007 Apr;47(4):430-44
pubmed: 17389552
Drug Metab Dispos. 2002 Jun;30(6):648-54
pubmed: 12019190
Drug Metab Dispos. 2009 Jan;37(1):82-9
pubmed: 18832476
Hum Mutat. 2015 Apr;36(4):395-402
pubmed: 25604253
Sci Rep. 2018 May 29;8(1):8234
pubmed: 29844446
Lancet. 2017 Sep 23;390(10101):1489-1498
pubmed: 28728956
PLoS One. 2013 Dec 11;8(12):e81302
pubmed: 24349052
Neuropsychiatr Dis Treat. 2016 Jul 22;12:1795-807
pubmed: 27524897
Muscle Nerve. 2006 Aug;34(2):135-44
pubmed: 16770791
Hum Mol Genet. 2012 Sep 15;21(18):4007-20
pubmed: 22692682
Mol Ther Nucleic Acids. 2017 Jun 16;7:417-428
pubmed: 28624217
Hum Mol Genet. 2017 Jul 1;26(13):2480-2492
pubmed: 28444310
Nature. 2007 May 3;447(7140):87-91
pubmed: 17450125
Drug Metab Dispos. 2008 May;36(5):870-7
pubmed: 18256202
Drug Metab Dispos. 2011 Nov;39(11):2117-29
pubmed: 21856742
Am J Hematol. 2018 Aug;93(4):527-536
pubmed: 29285795
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Oct 20;843(1):47-56
pubmed: 16815762
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3710-4
pubmed: 8475120
Drug Metab Dispos. 2012 May;40(5):1051-65
pubmed: 22357286
J Pharmacol Exp Ther. 1997 Jul;282(1):391-6
pubmed: 9223579
Drug Metab Dispos. 2012 Feb;40(2):276-82
pubmed: 22031623
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):E64; author reply E65
pubmed: 19506240
Lancet Neurol. 2010 Feb;9(2):177-89
pubmed: 19945914
Drug Metab Dispos. 2012 Apr;40(4):825-35
pubmed: 22275465
Drug Metab Dispos. 2020 Apr;48(4):317-325
pubmed: 31980502
Annu Rev Med. 2013;64:407-25
pubmed: 23215857
Clin Pharmacol Drug Dev. 2019 Feb;8(2):172-178
pubmed: 30629861