Elevated pre-transplant pulmonary vascular resistance is associated with early post-transplant atrial fibrillation and mortality.


Journal

ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191

Informations de publication

Date de publication:
02 2020
Historique:
received: 04 07 2019
revised: 16 09 2019
accepted: 04 10 2019
entrez: 21 3 2020
pubmed: 21 3 2020
medline: 27 5 2021
Statut: ppublish

Résumé

Severely elevated pre-transplant pulmonary vascular resistance (PVR) has been linked to adverse effects after heart transplantation (HTX). The impact of a moderately increased PVR before HTX on post-transplant outcomes remains uncertain. The aim of this study was to investigate the effects of an elevated pre-transplant PVR ≥ 300 dyn·s·cm This observational retrospective single-centre study included 561 patients receiving HTX at Heidelberg Heart Center between 1989 and 2015. Patients were stratified by degree of pre-transplant PVR. Analyses covered demographics, post-transplant medication, mortality and causes of death after HTX, early post-transplant atrial fibrillation (AF), and length of the initial hospital stay after HTX. Ninety-four patients (16.8%) had a PVR ≥ 300 dyn·s·cm Elevated pre-transplant PVR ≥ 300 dyn·s·cm

Identifiants

pubmed: 32197001
doi: 10.1002/ehf2.12549
pmc: PMC7083465
doi:

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

176-187

Subventions

Organisme : Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung
ID : Research Scholarship
Pays : International
Organisme : Medizinischen Fakultät Heidelberg, Universität Heidelberg
ID : Physician Scientist Program
Pays : International

Informations de copyright

© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

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Auteurs

Rasmus Rivinius (R)

Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Heidelberg Center for Heart Rhythm Disorders (HCR), Heidelberg University Hospital, Heidelberg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.

Matthias Helmschrott (M)

Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Arjang Ruhparwar (A)

Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Bastian Schmack (B)

Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Fabrice F Darche (FF)

Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Heidelberg Center for Heart Rhythm Disorders (HCR), Heidelberg University Hospital, Heidelberg, Germany.

Dierk Thomas (D)

Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Heidelberg Center for Heart Rhythm Disorders (HCR), Heidelberg University Hospital, Heidelberg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.

Tom Bruckner (T)

Institute for Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.

Andreas O Doesch (AO)

Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Department of Pneumology and Oncology, Asklepios Hospital, Bad Salzungen, Germany.

Hugo A Katus (HA)

Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Heidelberg Center for Heart Rhythm Disorders (HCR), Heidelberg University Hospital, Heidelberg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.

Philipp Ehlermann (P)

Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.

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