Cancer Genetics and Therapeutic Opportunities in Urologic Practice.
cancer genetics
next-generation sequencing
urologic oncology
urology
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
18 Mar 2020
18 Mar 2020
Historique:
received:
31
01
2020
revised:
13
03
2020
accepted:
15
03
2020
entrez:
22
3
2020
pubmed:
22
3
2020
medline:
22
3
2020
Statut:
epublish
Résumé
This article aims to summarize the current literature on genetic alterations related to tumors of the genitourinary tract. Novel associations have recently been reported between specific DNA alterations and genitourinary malignancies. The most common cause of chromosome 3p loss in clear cell renal cell carcinoma is a chromothripsis event, which concurrently generates a chromosome 5q gain. Specific patterns of clear cell renal cell carcinoma metastatic evolution have been uncovered. The first therapy targeting a specific molecular alteration has now been approved for urothelial carcinoma. Germline mutations in DNA damage repair genes and the transcription factor HOXB13 are associated with prostate cancer and may be targeted therapeutically. The genetic associations noted across different genitourinary cancers can inform potential screening approaches and guide novel targeted treatment strategies.
Identifiants
pubmed: 32197306
pii: cancers12030710
doi: 10.3390/cancers12030710
pmc: PMC7140104
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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