Current and New Predictors for Treatment Response in Metastatic Colorectal Cancer. The Role of Circulating miRNAs as Biomarkers.
biomarkers
chemotherapy
colorectal cancer
microRNA
prediction
treatment response
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Mar 2020
18 Mar 2020
Historique:
received:
24
02
2020
revised:
12
03
2020
accepted:
16
03
2020
entrez:
22
3
2020
pubmed:
22
3
2020
medline:
2
12
2020
Statut:
epublish
Résumé
Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world. More than half of all CRC patients will eventually develop metastases and require treatment accordingly, but few validated predictive factors for response to systemic treatments exist. In order to ascertain which patients benefit from specific treatments, there is a strong need for new and reliable biomarkers. We conducted a comprehensive search using the PUBMED database, up to December 2019, in order to identify relevant studies on predictive biomarkers for treatment response in metastatic CRC. We will herein present the currently used and potential biomarkers for treatment response and bring up-to-date knowledge on the role of circulating microRNAs, associated with chemotherapy and targeted therapy regimens used in metastatic CRC treatment. Molecular, tumor-related, disease-related, clinical, and laboratory predictive markers for treatment response were identified, mostly proposed, with few validated. Several circulating microRNAs have already proven their role of prediction for treatment response in CRC, but future clinical studies are needed to confirm their role as biomarkers across large cohorts of patients.
Identifiants
pubmed: 32197436
pii: ijms21062089
doi: 10.3390/ijms21062089
pmc: PMC7139554
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Circulating MicroRNA
0
RNA, Neoplasm
0
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : UEFISCDI-BIOGENONCO
ID : grant, 10/01.09.2016 (MySMIS-Code: 105774).
Références
Ann Oncol. 2002 Feb;13(2):308-17
pubmed: 11886010
J Clin Oncol. 2000 Aug;18(16):2938-47
pubmed: 10944126
J Clin Oncol. 2009 Apr 20;27(12):1948-55
pubmed: 19255311
Ann Oncol. 2018 Jan 1;29(1):44-70
pubmed: 29155929
Br J Cancer. 2015 Feb 17;112(4):624-9
pubmed: 25584492
Ann Oncol. 2013 Oct;24 Suppl 6:vi64-72
pubmed: 24078664
Clin Cancer Res. 2000 Apr;6(4):1322-7
pubmed: 10778957
Crit Rev Oncol Hematol. 2011 Sep;79(3):224-50
pubmed: 20719530
Clin Colorectal Cancer. 2017 Mar;16(1):51-57
pubmed: 27522626
J Clin Oncol. 2007 May 1;25(13):1670-6
pubmed: 17470860
Cancer Biomark. 2009;5(4):167-75
pubmed: 19729826
Pharmacogenomics J. 2011 Dec;11(6):429-36
pubmed: 20585341
N Engl J Med. 2015 Jun 25;372(26):2509-20
pubmed: 26028255
Int J Colorectal Dis. 2013 Jun;28(6):887
pubmed: 22892985
JAMA Oncol. 2017 Feb 1;3(2):194-201
pubmed: 27722750
J Clin Oncol. 2001 Dec 1;19(23):4298-304
pubmed: 11731512
Oncotarget. 2017 Jul 28;8(43):74312-74319
pubmed: 29088787
Br J Cancer. 2013 Sep 3;109(5):1243-51
pubmed: 23922111
J Surg Oncol. 2013 Sep;108(4):230-5
pubmed: 23861214
Asian Pac J Cancer Prev. 2013;14(12):7421-6
pubmed: 24460313
J Clin Oncol. 2004 Jan 15;22(2):229-37
pubmed: 14657227
J Clin Oncol. 2008 Jun 1;26(16):2690-8
pubmed: 18509181
Eur J Cancer. 2015 Mar;51(5):587-94
pubmed: 25673558
Int J Colorectal Dis. 2002 Jan;17(1):46-9
pubmed: 12018454
Med Oncol. 2014 Jan;31(1):799
pubmed: 24310813
World J Gastroenterol. 2016 Aug 14;22(30):6944-54
pubmed: 27570430
World J Gastroenterol. 2017 Mar 14;23(10):1816-1827
pubmed: 28348487
Adv Cancer Res. 2017;135:119-149
pubmed: 28882220
Cancer. 2011 Oct 15;117(20):4623-32
pubmed: 21456008
Clin Colorectal Cancer. 2003 Feb;2(4):246-51
pubmed: 12620146
Eur J Cancer. 2016 Nov;68:51-59
pubmed: 27716478
Oncotarget. 2016 Nov 15;7(46):76250-76260
pubmed: 27788488
EBioMedicine. 2016 Oct;12:34-42
pubmed: 27720213
Anticancer Drugs. 2014 Mar;25(3):346-52
pubmed: 24304648
Ann Oncol. 2018 Mar 1;29(3):602-609
pubmed: 29228087
Br J Cancer. 2012 Apr 10;106(8):1406-14
pubmed: 22491422
Cancers (Basel). 2019 Jun 27;11(7):
pubmed: 31252648
Signal Transduct Target Ther. 2016 Jan 28;1:15004
pubmed: 29263891
Clin Cancer Res. 2012 Jul 15;18(14):3982-91
pubmed: 22661538
Oncotarget. 2016 May 31;7(22):33210-9
pubmed: 27120807
Clin Cancer Res. 2000 Dec;6(12):4797-802
pubmed: 11156237
Cancer Biol Ther. 2015;16(12):1726-37
pubmed: 26553611
Cochrane Database Syst Rev. 2016 Feb 12;2:CD008593
pubmed: 26869023
Carcinogenesis. 2015 Jan;36(1):82-6
pubmed: 25368035
Med Sci Monit. 2016 Sep 22;22:3352-3361
pubmed: 27654003
Mol Oncol. 2014 Feb;8(1):59-67
pubmed: 24119443
J Clin Med. 2016 Jan 14;5(1):
pubmed: 26784241
Cell Cycle. 2013 May 1;12(9):1385-94
pubmed: 23574723
N Engl J Med. 2000 Sep 28;343(13):905-14
pubmed: 11006366
Clin Cancer Res. 1998 Oct;4(10):2371-6
pubmed: 9796967
Clin Colorectal Cancer. 2019 Mar;18(1):e117-e129
pubmed: 30598357
Br J Cancer. 2015 Sep 29;113(7):1027-34
pubmed: 26355232
Cell Physiol Biochem. 2018;48(4):1628-1637
pubmed: 30071508
Clin Cancer Res. 2013 Dec 15;19(24):6751-65
pubmed: 24122793
IUBMB Life. 2014 Sep;66(9):645-54
pubmed: 25328987
World J Surg Oncol. 2013 Nov 28;11:306
pubmed: 24283603
Eur J Cancer. 2017 Oct;84:69-80
pubmed: 28787661
Br J Cancer. 2006 Mar 27;94(6):798-805
pubmed: 16508637
Ann Oncol. 2016 Aug;27(8):1386-422
pubmed: 27380959
Oncotarget. 2017 Jul 25;8(30):49807-49823
pubmed: 28591704
PLoS One. 2014 Jun 18;9(6):e99886
pubmed: 24940606
N Engl J Med. 2004 Jul 22;351(4):337-45
pubmed: 15269313
Int J Mol Sci. 2018 Jan 20;19(1):
pubmed: 29361687
BMC Cancer. 2012 Mar 08;12:83
pubmed: 22397399
Int J Cancer. 2019 May 1;144(9):2169-2180
pubmed: 30381824
Int J Colorectal Dis. 2011 Feb;26(2):143-51
pubmed: 21188390
Drugs. 2019 Sep;79(13):1375-1394
pubmed: 31347092
Ann Oncol. 2012 Oct;23(10):2479-516
pubmed: 23012255
Br J Cancer. 2000 Aug;83(4):431-7
pubmed: 10945486
Br J Cancer. 2015 Jun 9;112(12):1966-75
pubmed: 25973534
Br J Cancer. 2001 Aug 17;85(4):509-17
pubmed: 11506488
Int J Oncol. 2007 Aug;31(2):413-8
pubmed: 17611699
Clin Colorectal Cancer. 2001 Nov;1(3):175-8; discussion 179-81
pubmed: 12450432