The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet.
Artesunate
hyperlipidemia
metabolomics
ursolic acid
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
18 Mar 2020
18 Mar 2020
Historique:
received:
23
02
2020
revised:
15
03
2020
accepted:
16
03
2020
entrez:
22
3
2020
pubmed:
22
3
2020
medline:
17
12
2020
Statut:
epublish
Résumé
Artesunate was well known as an antimalarial drug. Our previous research found that it has hypolipidemia effects in rabbits fed with a high-fat diet, especially combined with ursolic acid. In this study, we reconfirmed the lipid-lowering effect of artesunate and ursolic acid in hamsters and analyzed the metabolic changes using gas chromatography time-of-flight mass spectrometry (GC/TOF MS). Compared with the model group, a variety of different metabolites of artesunate and ursolic acid, alone or in combination, were found and confirmed. These differential metabolites, including fatty acids, lipids, and amino acids, were involved in lipid metabolism, energy metabolism, and amino acid metabolism. It indicated that two agents of artesunate and ursolic acid could attenuate or normalize the metabolic transformation on these metabolic pathways.
Identifiants
pubmed: 32197531
pii: molecules25061392
doi: 10.3390/molecules25061392
pmc: PMC7144559
pii:
doi:
Substances chimiques
Triterpenes
0
Artesunate
60W3249T9M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Major National Science and Technology Program of China for Innovative Drug
ID : 2017ZX09101002-003-002
Organisme : The Shanghai Science and Technology Innovation Action Plan
ID : 19431901700
Organisme : Natural Science Foundation of Shanghai
ID : 18ZR1420600
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