The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli.
Arteries
/ physiopathology
Blood Coagulation
/ physiology
Blood Platelets
/ cytology
Erythrocytes
/ cytology
Fibrin
/ metabolism
Humans
Microscopy, Electron, Scanning
Pulmonary Embolism
/ diagnostic imaging
Thromboembolism
/ diagnostic imaging
Veins
/ physiopathology
Venous Thrombosis
/ diagnostic imaging
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 03 2020
20 03 2020
Historique:
received:
03
09
2019
accepted:
21
01
2020
entrez:
22
3
2020
pubmed:
22
3
2020
medline:
26
11
2020
Statut:
epublish
Résumé
Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how the composition of thrombi and emboli depends on their vascular origin and age. We quantified the structure and composition of arterial and venous thrombi and pulmonary emboli using high-resolution scanning electron microscopy. Arterial thrombi contained a surprisingly large amount of fibrin, in addition to platelets. The composition of pulmonary emboli mirrored the most distal part of venous thrombi from which they originated, which differed from the structure of the body and head of the same thrombi. All thrombi and emboli contained few biconcave red blood cells but many polyhedrocytes or related forms of compressed red blood cells, demonstrating that these structures are a signature of clot contraction in vivo. Polyhedrocytes and intermediate forms comprised the major constituents of venous thrombi and pulmonary emboli. The structures within all of the thrombi and emboli were very tightly packed, in contrast to clots formed in vitro. There are distinctive, reproducible differences among arterial and venous thrombi and emboli related to their origin, destination and duration, which may have clinical implications for the understanding and treatment of thrombotic disorders.
Identifiants
pubmed: 32198356
doi: 10.1038/s41598-020-59526-x
pii: 10.1038/s41598-020-59526-x
pmc: PMC7083848
doi:
Substances chimiques
Fibrin
9001-31-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5112Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL135254
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141462
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL116330
Pays : United States
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