Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes.

Adolescent Adult Aged Aged, 80 and over Aptitude / physiology Brain Cortical Thickness Career Choice Cerebral Cortex / growth & development Female Form Perception / genetics Gene Expression Regulation, Developmental Genome-Wide Association Study Humans Male Microfilament Proteins / genetics Middle Aged Principal Component Analysis RNA-Binding Proteins / genetics Transcriptome Visual Cortex / growth & development Young Adult rho GTP-Binding Proteins / genetics tau Proteins / genetics
brain development cortical surface area cortical thickness genome-wide association study occupational aptitude

Journal

Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718

Informations de publication

Date de publication:
01 06 2020
Historique:
pubmed: 22 3 2020
medline: 17 12 2021
entrez: 22 3 2020
Statut: ppublish

Résumé

We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade-albeit in a very limited manner-to behaviors as complex as the choice of one's occupation.

Identifiants

DOI: 10.1093/cercor/bhaa035 PMID: 32198502 PMC: PMC7947185
pubmed: 32198502
pii: 5810465
doi: 10.1093/cercor/bhaa035
pmc: PMC7947185
doi:

Substances chimiques

DAAM1 protein, human 0
IGF2BP1 protein, human 0
MAPT protein, human 0
Microfilament Proteins 0
RNA-Binding Proteins 0
tau Proteins 0
rho GTP-Binding Proteins EC 3.6.5.2

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4121-4139

Subventions

Organisme : NIA NIH HHS
ID : R01 AG064955
Pays : United States
Organisme : Medical Research Council
ID : MR/R024065/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K026992/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N027558/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701120
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0700704
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/F019394/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M013111/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1001245
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG022381
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050595
Pays : United States

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.

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Auteurs

Jean Shin (J)

The Hospital for Sick Children, University of Toronto, Toronto, M5G 0A4 ON, M5G 0A4, Canada.
Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, M4G 1R8 ON, Canada.

Shaojie Ma (S)

Department of Genetics, Yale University School of Medicine, New Haven, 06510 CT, USA.
Department of Neuroscience, Yale University School of Medicine, New Haven, 06510 CT, USA.

Edith Hofer (E)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, 8036 Graz, Austria.
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria.

Yash Patel (Y)

Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, M4G 1R8 ON, Canada.

Daniel E Vosberg (DE)

Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, M4G 1R8 ON, Canada.

Steven Tilley (S)

Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, M4G 1R8 ON, Canada.

Gennady V Roshchupkin (GV)

Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
Department of Medical Informatics, Erasmus MC, 3015 Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.

André M M Sousa (AMM)

Department of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, 06510 CT, USA.

Xueqiu Jian (X)

Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, 77030 Houston, 77030 TX, USA.

Rebecca Gottesman (R)

Johns Hopkins School of Medicine, Baltimore, 21205 MD, USA.

Thomas H Mosley (TH)

University of Mississippi Medical Center, Jackson, 39216 MS, USA.

Myriam Fornage (M)

Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, 77030 Houston, 77030 TX, USA.

Yasaman Saba (Y)

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, 8036 Graz, Austria.

Lukas Pirpamer (L)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, 8036 Graz, Austria.

Reinhold Schmidt (R)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, 8036 Graz, Austria.

Helena Schmidt (H)

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, 8036 Graz, Austria.

Amaia Carrion-Castillo (A)

Language and Genetics Department, Max Planck Institute for Psycholinguistics, 6525 Nijmegen, The Netherlands.

Fabrice Crivello (F)

Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique, et Université de Bordeaux, F-33000 Bordeaux, France.

Bernard Mazoyer (B)

Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique, et Université de Bordeaux, F-33000 Bordeaux, France.

Joshua C Bis (JC)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101 WA, USA.

Shuo Li (S)

Department of Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.

Qiong Yang (Q)

Department of Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.

Michelle Luciano (M)

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9YL Edinburgh, UK.
Department of Psychology, University of Edinburgh, EH8 9JZ Edinburgh, UK.

Sherif Karama (S)

Montreal Neurological Institute, McGill University, H3A 2B4 Montreal, QC, Canada.

Lindsay Lewis (L)

Montreal Neurological Institute, McGill University, H3A 2B4 Montreal, QC, Canada.

Mark E Bastin (ME)

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9YL Edinburgh, UK.
Centre for Clinical Brain Sciences, University of Edinburgh, EH8 9YL Edinburgh, UK.

Mathew A Harris (MA)

Centre for Clinical Brain Sciences, University of Edinburgh, EH8 9YL Edinburgh, UK.
Division of Psychiatry, University of Edinburgh, EH8 9JZ Edinburgh, UK.

Joanna M Wardlaw (JM)

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9YL Edinburgh, UK.
UK Dementia Research Institute, University of Edinburgh, EH8 9JZ Edinburgh, UK.

Ian E Deary (IE)

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9YL Edinburgh, UK.
Department of Psychology, University of Edinburgh, EH8 9JZ Edinburgh, UK.

Markus Scholz (M)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04109 Leipzig, Germany.
LIFE Research Center for Civilization Diseases, 04103 Leipzig, Germany.

Markus Loeffler (M)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04109 Leipzig, Germany.
LIFE Research Center for Civilization Diseases, 04103 Leipzig, Germany.

A Veronica Witte (AV)

Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.
Faculty of Medicine, CRC 1052 Obesity Mechanisms, University of Leipzig, 04109 Leipzig, Germany.
Day Clinic for Cognitive Neurology, University Hospital Leipzig, 04103 Leipzig, Germany.

Frauke Beyer (F)

Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.
Faculty of Medicine, CRC 1052 Obesity Mechanisms, University of Leipzig, 04109 Leipzig, Germany.

Arno Villringer (A)

Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.
Faculty of Medicine, CRC 1052 Obesity Mechanisms, University of Leipzig, 04109 Leipzig, Germany.
Day Clinic for Cognitive Neurology, University Hospital Leipzig, 04103 Leipzig, Germany.

Nicola J Armstrong (NJ)

Mathematics and Statistics, Murdoch University, 6150 Perth, WA, Australia.

Karen A Mather (KA)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
Neuroscience Research Australia, 2031 Sydney, NSW, Australia.

David Ames (D)

National Ageing Research Institute, Royal Melbourne Hospital, 3052 Melbourne, VIC, Australia.
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, 3010 Melbourne, VIC, Australia.

Jiyang Jiang (J)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.

John B Kwok (JB)

Brain and Mind Centre, The University of Sydney, 2050 Sydney, NSW, Australia.
School of Medical Sciences, University of New South Wales, 2052 Sydney, NSW, Australia.

Peter R Schofield (PR)

Neuroscience Research Australia, 2031 Sydney, NSW, Australia.
School of Medical Sciences, University of New South Wales, 2052 Sydney, NSW, Australia.

Anbupalam Thalamuthu (A)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.

Julian N Trollor (JN)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, 2031 Sydney, NSW, Australia.

Margaret J Wright (MJ)

Queensland Brain Institute, The University of Queensland, 4072 St Lucia, QLD, Australia.
Centre for Advanced Imaging, The University of Queensland, 4072 St Lucia, QLD, Australia.

Henry Brodaty (H)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
Dementia Centre for Research Collaboration, University of New South Wales, 2052 Sydney, NSW, Australia.

Wei Wen (W)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.

Perminder S Sachdev (PS)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
Neuropsychiatric Institute, Prince of Wales Hospital, 2031 Sydney, NSW, Australia.

Natalie Terzikhan (N)

Department of Epidemiology, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.

Tavia E Evans (TE)

Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.

Hieab H H H Adams (HHHH)

Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.

M Arfan Ikram (MA)

Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
Department of Neurology, Erasmus MC University Medical Centre, 3015 Rotterdam, The Netherlands.

Stefan Frenzel (S)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489 Greifswald, Germany.

Sandra van der Auwera-Palitschka (SV)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489 Greifswald, Germany.
44German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, 37075, Germany.

Katharina Wittfeld (K)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489 Greifswald, Germany.
44German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, 37075, Germany.

Robin Bülow (R)

Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, 17489 Greifswald, Germany.

Hans Jörgen Grabe (HJ)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489 Greifswald, Germany.
44German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, 37075, Germany.

Christophe Tzourio (C)

Inserm, Bordeaux Population Health Research Center, University of Bordeaux, Team VINTAGE, UMR 1219, F-33000 Bordeaux, France.
Department of Neurology, CHU de Bordeaux, F-33000 Bordeaux, France.

Aniket Mishra (A)

Inserm, Bordeaux Population Health Research Center, University of Bordeaux, Team VINTAGE, UMR 1219, F-33000 Bordeaux, France.

Sophie Maingault (S)

Institut des Maladies Neurodégénratives, UMR 5293, CEA, CNRS, University of Bordeaux, Ubordeaux, F-33000 Bordeaux, France.

Stephanie Debette (S)

Inserm, Bordeaux Population Health Research Center, University of Bordeaux, Team VINTAGE, UMR 1219, F-33000 Bordeaux, France.
Department of Neurology, CHU de Bordeaux, F-33000 Bordeaux, France.
Department of Neurology, Boston University School of Medicine, Boston, 02118 MA, USA.

Nathan A Gillespie (NA)

Virginia Institute for Psychiatric and Behavioural Genetics, Virginia Commonwealth University, Richmond, 23284 VA, USA.

Carol E Franz (CE)

Department of Psychiatry, University of California, San Diego, 92093 CA, USA.
Center for Behavior Genetics of Aging, University of California, San Diego, 92093 CA, USA.

William S Kremen (WS)

Department of Psychiatry, University of California, San Diego, 92093 CA, USA.
Center for Behavior Genetics of Aging, University of California, San Diego, 92093 CA, USA.
VA San Diego Center of Excellence for Stress and Mental Health, San Diego, 92161 CA, USA.

Linda Ding (L)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, 90033 CA, USA.

Neda Jahanshad (N)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, 90033 CA, USA.

Nenad Sestan (N)

Department of Genetics, Yale University School of Medicine, New Haven, 06510 CT, USA.
Department of Neuroscience, Yale University School of Medicine, New Haven, 06510 CT, USA.

Zdenka Pausova (Z)

The Hospital for Sick Children, University of Toronto, Toronto, M5G 0A4 ON, M5G 0A4, Canada.
Department of Physiology, University of Toronto, Toronto, M5S 1A8 ON, Canada.
Department of Nutritional Sciences, University of Toronto, Toronto, M5S 1A8 ON, Canada.

Sudha Seshadri (S)

Department of Neurology, Boston University School of Medicine, Boston, 02118 MA, USA.
55Department of Epidemiology and Biostatistics, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, 78229 TX, USA.

Tomas Paus (T)

Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, M4G 1R8 ON, Canada.
Department of Psychology, University of Toronto, Toronto, M5S 3G3 ON, Canada.
Department of Psychiatry, University of Toronto, Toronto, M5T 1R8 ON, Canada.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Global and Regional Development of the Human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Global and Regional Development of the Human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Global and Regional Development of the Human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Global and Regional Development of the Human...
questionsmedicales.fr › Phénomènes psychologiques › Psychologie appliquée › Aptitude › Global and Regional Development of the Human...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Épaisseur corticale du cerveau › Global and Regional Development of the Human...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Pensée (activité mentale) › Prise de décision › Comportement de choix › Choix de carrière › Global and Regional Development of the Human...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Global and Regional Development of the Human...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception de l'espace › Perception de la forme › Global and Regional Development of the Human...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Global and Regional Development of the Human...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Global and Regional Development of the Human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Global and Regional Development of the Human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Global and Regional Development of the Human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Global and Regional Development of the Human...
questionsmedicales.fr › Techniques d'investigation › Analyse en composantes principales › Global and Regional Development of the Human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Global and Regional Development of the Human...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Global and Regional Development of the Human...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex visuel › Global and Regional Development of the Human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Global and Regional Development of the Human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Global and Regional Development of the Human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Global and Regional Development of the Human...