Medical comorbidities and endocrine dysfunction in low-weight females with avoidant/restrictive food intake disorder compared to anorexia nervosa and healthy controls.
Adolescent
Adult
Anorexia Nervosa
/ physiopathology
Avoidant Restrictive Food Intake Disorder
Case-Control Studies
Child
Comorbidity
/ trends
Cross-Sectional Studies
Endocrine System Diseases
/ complications
Feeding and Eating Disorders
/ complications
Female
Humans
Retrospective Studies
Young Adult
anorexia nervosa
avoidant/restrictive food intake disorder
hormone evaluation
low weight
medical comorbidities
Journal
The International journal of eating disorders
ISSN: 1098-108X
Titre abrégé: Int J Eat Disord
Pays: United States
ID NLM: 8111226
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
21
01
2020
revised:
26
02
2020
accepted:
02
03
2020
pubmed:
22
3
2020
medline:
11
11
2020
entrez:
22
3
2020
Statut:
ppublish
Résumé
To improve our understanding of medical complications and endocrine alterations in patients with low-weight avoidant/restrictive food intake disorder (ARFID) and how they may differ from those in anorexia nervosa (AN) and healthy controls (HC). We performed an exploratory cross-sectional study comparing low-weight females with ARFID (n = 20) with females with AN (n = 42) and HC (n = 49) with no history of an eating disorder. We found substantial overlap in medical comorbidities and endocrine features in ARFID and AN, but with earlier onset of aberrant eating behaviors in ARFID. We also observed distinct medical and endocrine alterations in ARFID compared to AN, such as a greater prevalence of asthma, a lower number of menses missed in the preceding 9 months, higher total T3 levels, and lower total T4 : total T3 ratio; these differences persisted after adjusting for age and might reflect differences in pathophysiology, acuity of weight fluctuations, and/or nutritional composition of food consumed. These results highlight the need for prompt diagnosis and intensive therapeutic intervention from disease onset in ARFID.
Identifiants
pubmed: 32198943
doi: 10.1002/eat.23261
pmc: PMC7184800
mid: NIHMS1576053
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
631-636Subventions
Organisme : NIMH NIH HHS
ID : R01 MH116205
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH120568
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK040561
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108595
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH103402
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000170
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001102
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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