FoxP3 deficiency causes no inflammation or neurodegeneration in the murine brain.

Corpus callosum Cortex Microglia Myelin Regulatory T cells Scurfy

Journal

Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498

Informations de publication

Date de publication:
18 Mar 2020
Historique:
received: 17 10 2019
revised: 10 03 2020
accepted: 11 03 2020
pubmed: 22 3 2020
medline: 22 3 2020
entrez: 22 3 2020
Statut: aheadofprint

Résumé

Regulatory T cells (Treg) maintain immunological self-tolerance and their functional or numerical deficits are associated with progression of several neurological diseases. We examined the effects of Treg absence on the structure and integrity of the unchallenged murine brain. When compared to control, Treg-deficient FoxP3

Identifiants

DOI: 10.1016/j.jneuroim.2020.577216 PMID: 32199198
pubmed: 32199198
pii: S0165-5728(19)30535-1
doi: 10.1016/j.jneuroim.2020.577216
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

577216

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no competing interests.

Auteurs

Stefan Gingele (S)

Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Electronic address: Gingele.Stefan@mh-hannover.de.

Refik Pul (R)

Department of Neurology, University Medicine Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany. Electronic address: Refik.Pul@uk-essen.de.

Maryam Sardari (M)

Department of Neurology, University Medicine Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany. Electronic address: Maryam.Sardari@uk-essen.de.

Mina Borbor (M)

Department of Neurology, University Medicine Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany. Electronic address: Mina.Borbor@uk-essen.de.

Florian Henkel (F)

Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Electronic address: Florian.Henkel@stud.mh-hannover.de.

Thiemo M Moellenkamp (TM)

Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Electronic address: Thiemo.M.Moellenkamp@stud.mh-hannover.de.

Viktoria Gudi (V)

Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Electronic address: Gudi.Viktoria@mh-hannover.de.

Christine Happle (C)

Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Germany. Electronic address: Happle.Christine@mh-hannover.de.

Ruth Grychtol (R)

Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Germany. Electronic address: Grychtol.Ruth@mh-hannover.de.

Anika Habener (A)

Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Germany. Electronic address: Habener.Anika@mh-hannover.de.

Gesine Hansen (G)

Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Germany. Electronic address: Hansen.Gesine@MH-Hannover.de.

Dirk M Hermann (DM)

Department of Neurology, University Medicine Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany. Electronic address: Dirk.Hermann@uk-essen.de.

Martin Stangel (M)

Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Electronic address: Stangel.Martin@mh-hannover.de.

Christoph Kleinschnitz (C)

Department of Neurology, University Medicine Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany. Electronic address: Christoph.Kleinschnitz@uk-essen.de.

Jelena Skuljec (J)

Department of Neurology, University Medicine Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany. Electronic address: Jelena.Skuljec@uk-essen.de.

Classifications MeSH