The taming of PARP1 and its impact on NAD

Animals DNA Repair Histones / genetics Humans NAD / genetics Poly (ADP-Ribose) Polymerase-1 / genetics Poly(ADP-ribose) Polymerases / genetics Stress, Physiological / physiology
Epigenetics Homeostasis MacroH2A Metabolism NAD+ PARP1

Journal

Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730

Informations de publication

Date de publication:
08 2020
Historique:
received: 18 10 2019
revised: 10 01 2020
accepted: 24 01 2020
pubmed: 23 3 2020
medline: 29 6 2021
entrez: 23 3 2020
Statut: ppublish

Résumé

Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD In this review, we discuss how different organelles are linked through NAD The presence of macroH2A1.1, particularly in differentiated cells, raises the threshold for the activation of PARP1 with consequences for DNA repair, gene transcription, and NAD

Sections du résumé

BACKGROUND
Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD
SCOPE OF REVIEW
In this review, we discuss how different organelles are linked through NAD
MAJOR CONCLUSIONS
The presence of macroH2A1.1, particularly in differentiated cells, raises the threshold for the activation of PARP1 with consequences for DNA repair, gene transcription, and NAD

Identifiants

DOI: 10.1016/j.molmet.2020.01.014 PMID: 32199820 PMC: PMC7300387
pubmed: 32199820
pii: S2212-8778(20)30022-3
doi: 10.1016/j.molmet.2020.01.014
pmc: PMC7300387
pii:
doi:

Substances chimiques

Histones 0
NAD 0U46U6E8UK
PARP1 protein, human EC 2.4.2.30
Poly (ADP-Ribose) Polymerase-1 EC 2.4.2.30
Poly(ADP-ribose) Polymerases EC 2.4.2.30

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100950

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier GmbH.. All rights reserved.

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Auteurs

Sarah Hurtado-Bagès (S)

Josep Carreras Leukemia Research Institute, Campus ICO-Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916, Badalona, Spain; Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Gunnar Knobloch (G)

Biomedical Center Munich, Physiological Chemistry, Ludwig-Maximilians-Universität München, 82152, Planegg-Martinsried, Germany.

Andreas G Ladurner (AG)

Biomedical Center Munich, Physiological Chemistry, Ludwig-Maximilians-Universität München, 82152, Planegg-Martinsried, Germany; Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, 81377, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-Universität München, 81377, Munich, Germany. Electronic address: andreas.ladurner@bmc.med.lmu.de.

Marcus Buschbeck (M)

Josep Carreras Leukemia Research Institute, Campus ICO-Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916, Badalona, Spain; Program for Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), 08916, Badalona, Spain. Electronic address: mbuschbeck@carrerasresearch.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The taming of PARP1 and its impact on NAD
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › The taming of PARP1 and its impact on NAD
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › The taming of PARP1 and its impact on NAD
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The taming of PARP1 and its impact on NAD
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › The taming of PARP1 and its impact on NAD
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › Poly (ADP-Ribose) polymerase-1 › The taming of PARP1 and its impact on NAD
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › The taming of PARP1 and its impact on NAD
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › The taming of PARP1 and its impact on NAD