CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow.

Animals Antigens, CD / genetics Antigens, Differentiation, Myelomonocytic / genetics Bone Marrow Cells / immunology Cells, Cultured Cytokines / metabolism Dermatitis, Allergic Contact / immunology Disease Models, Animal Disease Susceptibility Humans Immunomodulation Inflammation / immunology Interferon Regulatory Factors / genetics Macrophage Activation Macrophages / immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Receptors, Cell Surface / genetics Staphylococcal Infections / immunology Staphylococcus aureus / physiology Transcriptome

IFN regulatory factor 8 Resident bone marrow macrophages scavenger receptor CD163 sterile and systemic inflammation

Journal

The Journal of allergy and clinical immunology

ISSN: 1097-6825

Titre abrégé: J Allergy Clin Immunol

Pays: United States

ID NLM: 1275002

Informations de publication

Date de publication:
11 2020

Historique:

received: 16 08 2019

revised: 13 01 2020

accepted: 11 02 2020

pubmed: 23 3 2020

medline: 16 3 2021

entrez: 23 3 2020

Statut: ppublish

Résumé

Scavenger receptor CD163 is exclusively expressed on monocytes/macrophages and is widely used as a marker for alternatively activated macrophages. However, the role of CD163 is not yet clear. We sought to examine the function of CD163 in steady-state as well as in sterile and infectious inflammation. Expression of CD163 was analyzed under normal and inflammatory conditions in mice. Functional relevance of CD163 was investigated in models of inflammation in wild-type and CD163 We describe a subpopulation of bone marrow-resident macrophages (BMRMs) characterized by a high expression of CD163 and functionally distinct from classical bone marrow-derived macrophages. Development of CD163 Our data indicate that anti-inflammatory and immunosuppressive mechanisms are not necessarily associated with a decreased antimicrobial activity. In contrast, our data define a novel macrophage population that controls overwhelming inflammation on one hand but is also necessary for an effective control of infections on the other hand.

Sections du résumé

BACKGROUND

Scavenger receptor CD163 is exclusively expressed on monocytes/macrophages and is widely used as a marker for alternatively activated macrophages. However, the role of CD163 is not yet clear.

OBJECTIVES

We sought to examine the function of CD163 in steady-state as well as in sterile and infectious inflammation.

METHODS

Expression of CD163 was analyzed under normal and inflammatory conditions in mice. Functional relevance of CD163 was investigated in models of inflammation in wild-type and CD163

RESULTS

We describe a subpopulation of bone marrow-resident macrophages (BMRMs) characterized by a high expression of CD163 and functionally distinct from classical bone marrow-derived macrophages. Development of CD163

CONCLUSIONS

Our data indicate that anti-inflammatory and immunosuppressive mechanisms are not necessarily associated with a decreased antimicrobial activity. In contrast, our data define a novel macrophage population that controls overwhelming inflammation on one hand but is also necessary for an effective control of infections on the other hand.

Identifiants

DOI: 10.1016/j.jaci.2020.02.034 PMID: 32199911

pubmed: 32199911

pii: S0091-6749(20)30344-4

doi: 10.1016/j.jaci.2020.02.034

pii:

doi:

Substances chimiques

Antigens, CD 0

Antigens, Differentiation, Myelomonocytic 0

CD163 antigen 0

Cytokines 0

Interferon Regulatory Factors 0

Receptors, Cell Surface 0

interferon regulatory factor-8 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1137-1151