Immunopathological characterization of red focal changes in Atlantic salmon (Salmo salar) white muscle.
Atlantic salmon
Inflammation
Piscine orthoreovirus
Journal
Veterinary immunology and immunopathology
ISSN: 1873-2534
Titre abrégé: Vet Immunol Immunopathol
Pays: Netherlands
ID NLM: 8002006
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
16
09
2019
revised:
26
02
2020
accepted:
06
03
2020
pubmed:
23
3
2020
medline:
21
10
2020
entrez:
23
3
2020
Statut:
ppublish
Résumé
Farmed Atlantic salmon (Salmo salar) are prone to various conditions affecting the quality of the fillet. A well-known but so far poorly understood condition is the focal red changes in muscle, often referred to as haemorrhages. Such changes are characterized by muscle necrosis, haemorrhages and acute inflammation. They can progress into focal melanised changes, a chronic inflammatory condition with melanin-producing leukocytes. The initial cause of intramuscular haemorrhages is unknown. In this study, we aimed to reveal some of their key immunological features. Samples of red focal changes were investigated by immunohistochemistry (IHC), in situ hybridization (ISH) and RT-qPCR for various immune markers. The results were compared with samples of melanised changes and control muscle, subjected to the same analyses. In all red changes, infiltrates with mononuclear cells were detected, consisting mostly of MHC class I/II
Identifiants
pubmed: 32200172
pii: S0165-2427(20)30061-1
doi: 10.1016/j.vetimm.2020.110035
pii:
doi:
Substances chimiques
Biomarkers
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110035Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no competing interests.