Cell Plasticity in Liver Regeneration.
cell plasticity
epigenetic regulation
liver injury
regeneration
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
03
12
2019
revised:
15
01
2020
accepted:
17
01
2020
entrez:
24
3
2020
pubmed:
24
3
2020
medline:
25
6
2021
Statut:
ppublish
Résumé
The liver, whose major functional cell type is the hepatocyte, is a peculiar organ with remarkable regenerative capacity. The widely held notion that hepatic progenitor cells contribute to injury-induced liver regeneration has long been debated. However, multiple lines of evidence suggest that the plasticity of differentiated cells is a major mechanism for the cell source in injury-induced liver regeneration. Investigating cell plasticity could potentially expand our understanding of liver physiology and facilitate the development of new therapies for liver diseases. In this review, we summarize the cell sources for hepatocyte regeneration and the clinical relevance of cell plasticity for human liver diseases. We focus on mechanistic insights on the injury-induced cell plasticity of hepatocytes and biliary epithelial cells and discuss future directions for investigation. Specifically, we propose the notion of 'reprogramming competence' to explain the plasticity of differentiated hepatocytes.
Identifiants
pubmed: 32200807
pii: S0962-8924(20)30019-2
doi: 10.1016/j.tcb.2020.01.007
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
329-338Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.