The Crosstalk between lncRNA-SNHG7/miRNA-181/cbx7 Modulates Malignant Character in Lung Adenocarcinoma.
Adenocarcinoma of Lung
/ genetics
Animals
Cell Line, Tumor
Cell Movement
/ physiology
Cell Proliferation
/ genetics
Down-Regulation
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms
/ genetics
Male
Mice
MicroRNAs
/ genetics
Polycomb Repressive Complex 1
/ genetics
RNA, Long Noncoding
/ genetics
Signal Transduction
/ physiology
Journal
The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
14
11
2019
revised:
29
01
2020
accepted:
18
02
2020
pubmed:
24
3
2020
medline:
23
6
2020
entrez:
24
3
2020
Statut:
ppublish
Résumé
Lung adenocarcinoma (LUAD) is a malignant tumor with poor patient survival and high patient mortality. Long noncoding RNA is profoundly involved in the tumorigenesis of LUAD. The present study explores the effect of small nucleolar RNA host gene 7 (SNHG7) on the progression of LUAD and its underlying mechanisms. SNHG7 was found to be down-regulated in LUAD tissues compared with normal tissues. Altered SNHG7 expression induced changes in cell proliferation and migration both in vitro and in vivo. Mechanistically, it was found that SNHG7 interacted with microRNA mir-181 and sequentially up-regulated cbx7. cbx7, which suppresses the Wnt/β-catenin pathway in LUAD, was found to be a direct target of mir-181. Taken together, loss of SNHG7 in LUAD up-regulated mir-181 and then down-regulated the tumor suppressor cbx7.
Identifiants
pubmed: 32201260
pii: S0002-9440(20)30132-2
doi: 10.1016/j.ajpath.2020.02.011
pii:
doi:
Substances chimiques
CBX7 protein, human
0
MIRN-181 microRNA, human
0
MicroRNAs
0
RNA, Long Noncoding
0
Polycomb Repressive Complex 1
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1343-1354Informations de copyright
Copyright © 2020 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.