Greater Skeletal Muscle Oxidative Capacity Is Associated With Higher Resting Metabolic Rate: Results From the Baltimore Longitudinal Study of Aging.
Adult
Aged
Aged, 80 and over
Aging
/ metabolism
Baltimore
Basal Metabolism
/ physiology
Body Composition
Calorimetry, Indirect
Chronic Disease
/ epidemiology
Cross-Sectional Studies
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Mitochondria, Muscle
/ metabolism
Muscle, Skeletal
/ metabolism
Oxygen Consumption
/ physiology
Prospective Studies
Biology of aging
Metabolism
Mitochondria
Muscles
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837
Informations de publication
Date de publication:
13 11 2020
13 11 2020
Historique:
received:
10
12
2019
pubmed:
24
3
2020
medline:
23
2
2021
entrez:
24
3
2020
Statut:
ppublish
Résumé
Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is similar to changes that occur in muscle mass, muscle strength, and fitness, but while the decline in these phenotypes has been related to changes of mitochondrial function and oxidative capacity, whether lower RMR is associated with poorer mitochondrial oxidative capacity is unknown. In 619 participants of the Baltimore Longitudinal Study of Aging, we analyzed the cross-sectional association between RMR (kcal/day), assessed by indirect calorimetry, and skeletal muscle maximal oxidative phosphorylation capacity, assessed as postexercise phosphocreatine recovery time constant (τ PCr), by phosphorous magnetic resonance spectroscopy. Linear regression models were used to evaluate the relationship between τ PCr and RMR, adjusting for potential confounders. Independent of age, sex, lean body mass, muscle density, and fat mass, higher RMR was significantly associated with shorter τ PCr, indicating greater mitochondrial oxidative capacity. Higher RMR is associated with a higher mitochondrial oxidative capacity in skeletal muscle. This association may reflect a relationship between better muscle quality and greater mitochondrial health.
Identifiants
pubmed: 32201887
pii: 5810914
doi: 10.1093/gerona/glaa071
pmc: PMC7751004
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2262-2268Subventions
Organisme : NIA NIH HHS
ID : R01 AG057723
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG027012
Pays : United States
Informations de copyright
Published by Oxford University Press on behalf of The Gerontological Society of America 2020.
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