Functional correlation between choroidal and retinal vascularity in low-grade diabetic retinopathy.
Aged
Case-Control Studies
Choroid
/ blood supply
Diabetes Mellitus
/ diagnosis
Diabetic Retinopathy
/ diagnosis
Disease Progression
Female
Fluorescein Angiography
/ methods
Humans
Male
Microvessels
/ diagnostic imaging
Middle Aged
Retina
/ diagnostic imaging
Retinal Vessels
/ diagnostic imaging
Retrospective Studies
Severity of Illness Index
Tomography, Optical Coherence
/ methods
Choriocapillaris
Choroid
Diabetic choroidopathy
Diabetic retinopathy
OCT-angiography
Optical coherence tomography angiography
Journal
Acta diabetologica
ISSN: 1432-5233
Titre abrégé: Acta Diabetol
Pays: Germany
ID NLM: 9200299
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
08
01
2020
accepted:
14
02
2020
pubmed:
24
3
2020
medline:
24
9
2020
entrez:
24
3
2020
Statut:
ppublish
Résumé
To perform an automated functional assessment of retinal and choroidal microvasculature in eyes with low-grade diabetic retinopathy (DR) using optical coherence tomography angiography (OCT-A) and to identify potential perfusion changes in case of early vascular damage. This is an observational, case-control study of consecutive diabetic patients with level 20 DR severity scale score and age-matched healthy subjects. A prototypal OCT-angiography was used to obtain the OCT-angiograms of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) layer. A validated automated microstructural analysis provided data on SCP, DCP and CC vascular perfusion density (VPD). A comparative assessment between different vascular layers and different groups was performed. Twenty-nine diabetic patients (7 females, 24%) and 20 healthy controls were enrolled. VPD values were significantly lower in the DCP (25.1% vs. 26.5%; p = 0.04) and CC (71.2% vs. 86.6%; p = 0.0001) of diabetic patients compared with controls. A statistically significant negative linear correlation was reported between CC VPD and DCP VPD in diabetic patients; at the reverse, a positive linear correlation between the same parameters was noticed in controls. Retinal and choroidal vascular networks, although distinct entities, seem functionally interconnected: varying the degree of perfusion may be a mutual compensatory mechanism in response to an ischemic injury.
Identifiants
pubmed: 32201906
doi: 10.1007/s00592-020-01507-7
pii: 10.1007/s00592-020-01507-7
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
983-990Références
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