Autoimmune responses and inflammation in type 2 diabetes.
adipose tissue
autoimmunity
inflammation
obesity
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
21
11
2019
revised:
14
02
2020
accepted:
03
03
2020
pubmed:
24
3
2020
medline:
5
11
2020
entrez:
24
3
2020
Statut:
ppublish
Résumé
Obesity-induced insulin resistance is one of the largest noncommunicable disease epidemics that we are facing at the moment. Changes in lifestyle and greater availability of low nutritional value, high caloric food has led to the highest rates of obesity in history. Obesity impacts the immune system and obesity-associated inflammation contributes to metabolic diseases, such as type 2 diabetes. Both the adaptive and the innate immune system play a role in the regulation of glycemic control, and there is a need to understand how metabolic imbalances drive disease pathogenesis. This review discusses the cell types, mediators, and pathways that contribute to immunologic-metabolic crosstalk and explores how the immune system might be targeted as a strategy to treat metabolic disease.
Identifiants
pubmed: 32202348
doi: 10.1002/JLB.3MR0220-243R
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
739-748Informations de copyright
©2020 Society for Leukocyte Biology.
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