Leaking chemokines confuse neutrophils.
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
01 05 2020
01 05 2020
Historique:
pubmed:
24
3
2020
medline:
22
1
2021
entrez:
24
3
2020
Statut:
ppublish
Résumé
The physical integrity of endothelial cells (ECs) lining the blood vessels regulates the inflammatory response. Both innate immunity and inflammatory disorders hinge on the EC-neutrophil interaction. Neutrophil binding, rolling, and migrating along and between ECs is associated with vascular permeability. In this issue of the JCI, Owen-Woods et al. tracked neutrophils in vivo in venules of mouse striated muscle and revealed how endothelial permeability can affect neutrophil trafficking. Strikingly, many neutrophils that migrated between EC junctions were able to rejoin the blood circulation. Further, the chemokine and neutrophil chemoattractant, CXCL1, drove this reverse transendothelial migration (rTEM). This paradigm-shifting study provides a mechanism for distal organ damage as well as an explanation for sepsis-associated acute respiratory distress syndrome.
Identifiants
pubmed: 32202515
pii: 136259
doi: 10.1172/JCI136259
pmc: PMC7190970
doi:
pii:
Substances chimiques
Chemokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
2177-2179Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL078784
Pays : United States
Commentaires et corrections
Type : CommentOn
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