DNA methylation disruption reshapes the hematopoietic differentiation landscape.
Animals
Cell Differentiation
/ genetics
DNA (Cytosine-5-)-Methyltransferases
/ genetics
DNA Methylation
/ genetics
DNA-Binding Proteins
/ genetics
Hematopoiesis
/ genetics
Hematopoietic Stem Cells
/ physiology
Humans
Male
Mice
Mice, Transgenic
Mutation
/ genetics
Transcription, Genetic
/ genetics
Transcriptome
/ genetics
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
16
04
2019
accepted:
19
02
2020
pubmed:
24
3
2020
medline:
27
6
2020
entrez:
24
3
2020
Statut:
ppublish
Résumé
Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A) are frequently observed in hematological malignancies
Identifiants
pubmed: 32203468
doi: 10.1038/s41588-020-0595-4
pii: 10.1038/s41588-020-0595-4
pmc: PMC7216752
mid: NIHMS1564247
doi:
Substances chimiques
DNA-Binding Proteins
0
DNA (Cytosine-5-)-Methyltransferases
EC 2.1.1.37
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
378-387Subventions
Organisme : NCI NIH HHS
ID : R00 CA218896
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128239
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA215317
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122515
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL145283
Pays : United States
Organisme : NCI NIH HHS
ID : DP2 CA239065
Pays : United States
Commentaires et corrections
Type : CommentIn
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