Macrophages represent the major pool of IL-7Rα expressing cells in patients with myocarditis.

Immune cells Inflammation Interleukin-7 receptor-α Macrophages Myocarditis

Journal

Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353

Informations de publication

Date de publication:
20 Mar 2020
Historique:
received: 21 08 2019
revised: 02 02 2020
accepted: 24 02 2020
pubmed: 24 3 2020
medline: 24 3 2020
entrez: 24 3 2020
Statut: aheadofprint

Résumé

Myocarditis is characterized by infiltration and activation of cytokine as well as chemokine receptors frequently producing heart failure. Causes are often infections triggering inflammatory and immune responses but these initial lines of defense might be finally disastrous. To identify mediators we screened various receptors by confocal microscopy and identified cardiac interleukin-7 (IL-7) receptor-α (IL-7Rα) expressing cells in patients with myocarditis. IL-7Rα

Identifiants

pubmed: 32203694
pii: S1043-4666(20)30069-7
doi: 10.1016/j.cyto.2020.155053
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

155053

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Natalia Kubin (N)

Department of Cardiac Surgery, Kerckhoff-Clinic, Benekestrasse 2-8, Bad Nauheim 61231, Germany.

Manfred Richter (M)

Department of Cardiac Surgery, Kerckhoff-Clinic, Benekestrasse 2-8, Bad Nauheim 61231, Germany. Electronic address: m.richter@kerckhoff-klinik.de.

Bedriye Sen-Hild (B)

Pediatric Heart Center, Justus Liebig University, Feulgenstrasse 10-12, Giessen 35392, Germany.

Hakan Akintürk (H)

Pediatric Heart Center, Justus Liebig University, Feulgenstrasse 10-12, Giessen 35392, Germany.

Markus Schönburg (M)

Department of Cardiac Surgery, Kerckhoff-Clinic, Benekestrasse 2-8, Bad Nauheim 61231, Germany.

Thomas Kubin (T)

Department of Cardiac Surgery, Kerckhoff-Clinic, Benekestrasse 2-8, Bad Nauheim 61231, Germany.

Ayse Cetinkaya (A)

Department of Cardiac Surgery, Kerckhoff-Clinic, Benekestrasse 2-8, Bad Nauheim 61231, Germany.

Classifications MeSH