Cytotoxic xanthone derivatives from the twigs of Garcinia oligantha.
Cytotoxic activity
Garcinia oligantha merr.
Xanthone derivatives
clusiaceae
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
10
12
2019
revised:
25
01
2020
accepted:
24
02
2020
pubmed:
24
3
2020
medline:
1
5
2020
entrez:
24
3
2020
Statut:
ppublish
Résumé
Ten undescribed xanthone derivatives, garoliganthins A-I and oliganthaxanthone C, along with eight known compounds, were isolated from the twigs of Garcinia oligantha Merr. Their structures and absolute configurations were determined by extensive spectroscopic methods, single-crystal X-ray diffraction analysis, electronic circular dichroism analysis, and chiral HPLC/HPLC-CD analysis combined with density functional theory calculations. Garoliganthin A is an unprecedented tetrahydro-xanthone derivative possessing a bicycle [3.2.2] nonane skeleton, and garoliganthins B-E are the first examples of a new class of rearranged xanthone derivatives with six-membered lactone core scaffold. The cytotoxic effects of the isolates on four human cancer cell lines (HeLa, PC-3, A549, and K562) were measured using an MTT assay. Seven compounds showed good inhibitory activities against four cancer cell lines with IC
Identifiants
pubmed: 32203742
pii: S0031-9422(19)31192-6
doi: 10.1016/j.phytochem.2020.112329
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Xanthones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112329Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declared that they have no conflicts of interest to this work. We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.