Brain-wide representations of ongoing behavior: a universal principle?
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
23
01
2020
revised:
16
02
2020
accepted:
17
02
2020
pubmed:
24
3
2020
medline:
28
1
2021
entrez:
24
3
2020
Statut:
ppublish
Résumé
Recent neuronal activity recordings of unprecedented breadth and depth in worms, flies, and mice have uncovered a surprising common feature: brain-wide behavior-related signals. These signals pervade, and even dominate, neuronal populations thought to function primarily in sensory processing. Such convergent findings across organisms suggest that brain-wide representations of behavior might be a universal neuroscientific principle. What purpose(s) do these representations serve? Here we review these findings along with suggested functions, including sensory prediction, context-dependent sensory processing, and, perhaps most speculatively, distributed motor command generation. It appears that a large proportion of the brain's energy and coding capacity is used to represent ongoing behavior; understanding the function of these representations should therefore be a major goal in neuroscience research.
Identifiants
pubmed: 32203874
pii: S0959-4388(20)30046-5
doi: 10.1016/j.conb.2020.02.008
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
60-69Subventions
Organisme : Wellcome Trust
ID : 208565/A/17/Z
Pays : United Kingdom
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.