Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats.
Animals
Anti-Ulcer Agents
/ chemistry
Antioxidants
/ chemistry
Body Weight
Disease Models, Animal
Fermented Foods
Gastric Mucosa
/ drug effects
Glutathione Peroxidase
/ metabolism
Immunohistochemistry
Lotus
/ chemistry
Male
NF-kappa B
/ metabolism
Oxidative Stress
/ drug effects
Plant Extracts
/ chemistry
Plant Roots
/ chemistry
Protective Agents
/ chemistry
RNA, Messenger
/ genetics
Rats
Stomach Ulcer
/ drug therapy
anti-inflammatory effect
antioxidant effect
fermented lotus root
gastric ulcer
gastroprotective effect
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
19 Mar 2020
19 Mar 2020
Historique:
received:
21
02
2020
revised:
16
03
2020
accepted:
17
03
2020
entrez:
25
3
2020
pubmed:
25
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Gastric ulcers are a common gastrointestinal disease across the globe. Alcohol consumption is the primary cause of gastric carcinogenesis and progression. We investigated the gastroprotective effects of fermented lotus root (FL) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model and the conceivable underlying mechanisms involved. Rats received different doses of FL (50, 100, and 200 mg/kg) or ranitidine (positive control, 30 mg/kg) via oral gavage daily for 14 days. One hour after the last oral administration of FL, the EtOH/HCl mixture was orally intubated to induce gastric damage. Oral administration of FL significantly alleviated the gastric lesions. Moreover, FL also elevated the amounts of nitric oxide and the antioxidant enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase in the stomach. To verify the gastric mucosal defense mechanism, inflammation-related genes were measured. Our results revealed that FL effectively inhibited gastric mucosal damage via downregulation of the nuclear factor-kappaB (NF-κB) response in the stomach. The administration of FL significantly lowered the gastric mRNA expression of inflammation-related genes, including
Identifiants
pubmed: 32204312
pii: nu12030808
doi: 10.3390/nu12030808
pmc: PMC7146638
pii:
doi:
Substances chimiques
Anti-Ulcer Agents
0
Antioxidants
0
NF-kappa B
0
Plant Extracts
0
Protective Agents
0
RNA, Messenger
0
Glutathione Peroxidase
EC 1.11.1.9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Agriculture, Food and Rural Affairs
ID : Food Functionality Evaluation program
Références
J Clin Biochem Nutr. 2012 Jan;50(1):35-9
pubmed: 22247598
Emerg Med Clin North Am. 1990 Nov;8(4):859-72
pubmed: 2226291
Evid Based Complement Alternat Med. 2015;2015:789124
pubmed: 27057194
Physiol Rev. 2014 Apr;94(2):329-54
pubmed: 24692350
Oxid Med Cell Longev. 2016;2016:3164734
pubmed: 26881021
Int Immunopharmacol. 2015 Sep;28(1):604-15
pubmed: 26241782
J Clin Gastroenterol. 1992;14 Suppl 1:S131-4
pubmed: 1629568
Anal Biochem. 1979 Jun;95(2):351-8
pubmed: 36810
Drugs. 1992 Nov;44(5):709-19
pubmed: 1280563
Food Sci Nutr. 2018 Oct 01;6(8):2036-2046
pubmed: 30510705
Indian J Physiol Pharmacol. 2004 Jan;48(1):115-8
pubmed: 15270379
World J Gastroenterol. 2008 Oct 14;14(38):5857-67
pubmed: 18855985
J Ethnopharmacol. 2010 Mar 24;128(2):490-4
pubmed: 20079418
J Pharm Pharmacol. 2009 Apr;61(4):407-22
pubmed: 19298686
Biomed Pharmacother. 2017 Nov;95:1139-1146
pubmed: 28926923
Arthritis Res Ther. 2008;10 Suppl 2:S4
pubmed: 19007429
J Dairy Sci. 2018 May;101(5):3758-3770
pubmed: 29477532
Toxins (Basel). 2017 Mar 28;9(4):
pubmed: 28350359
Proc Soc Exp Biol Med. 1987 Sep;185(4):493-7
pubmed: 3497403
Cell Res. 2011 Jan;21(1):103-15
pubmed: 21187859
Prev Nutr Food Sci. 2015 Sep;20(3):162-8
pubmed: 26451352
Nutrients. 2016 May 13;8(5):
pubmed: 27187458
Gastroenterology. 2008 Jul;135(1):41-60
pubmed: 18549814
J Physiol Pharmacol. 2014 Oct;65(5):613-22
pubmed: 25371520
Nat Rev Immunol. 2017 Sep;17(9):545-558
pubmed: 28580957