Understanding the Synergy of NKp46 and Co-Activating Signals in Various NK Cell Subpopulations: Paving the Way for More Successful NK-Cell-Based Immunotherapy.
NK cell activating receptors
NK cell biology
NK cell subsets
cell adhesion molecules
cytotoxicity assay
degranulation
granule polarization
long-lived memory-like NK cells
trogocytosis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
19 03 2020
19 03 2020
Historique:
received:
11
02
2020
revised:
09
03
2020
accepted:
13
03
2020
entrez:
25
3
2020
pubmed:
25
3
2020
medline:
13
2
2021
Statut:
epublish
Résumé
The NK cell population is characterized by distinct NK cell subsets that respond differently to the various activating stimuli. For this reason, the determination of the optimal cytotoxic activation of the different NK cell subsets can be a crucial aspect to be exploited to counter cancer cells in oncologic patients. To evaluate how the triggering of different combination of activating receptors can affect the cytotoxic responses of different NK cell subsets, we developed a microbead-based degranulation assay. By using this new assay, we were able to detect CD107a
Identifiants
pubmed: 32204481
pii: cells9030753
doi: 10.3390/cells9030753
pmc: PMC7140651
pii:
doi:
Substances chimiques
CD56 Antigen
0
Interleukin-2
0
NCR1 protein, human
0
Natural Cytotoxicity Triggering Receptor 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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